Results 51 to 60 of about 21,290,016 (308)

Overexpression of HOTAIR leads to radioresistance of human cervical cancer via promoting HIF-1α expression

Radiation Oncology, 2018
Background HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported.
Ning Li, Dan-dan Meng, Ling Gao, Yue Xu, Pei-jie Liu, Yong-wei Tian, Zhen-ying Yi, Yan Zhang, Xiao-jing Tie, Zhi-qiao Xu   +9 more
doaj   +1 more source

Acromegaly: pathogenesis & treatment [PDF]

, 2019
Acromegaly is a multi-system disorder whose etiology is most often traced back to a growth hormone-secreting pituitary adenoma (PA). Growth hormone (GH) secretion promotes insulin-like growth factor 1 (IGF-1) release from peripheral tissues, leading to ...
Tilvawala, Megha
core  

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Evaluating IL22RA1 expression as a predictive indicator in human colon cancer progression

BMC Cancer
Background Colon cancer is a prevalent malignancy of the digestive tract, consistently ranking among the top three cancers globally in both incidence and mortality.
Xuan Yin, Renhao Geng, Junjun Chen, Bin Xu, Hui Ma, Yingting Liu, Xiao Zheng, Lujun Chen   +7 more
doaj   +1 more source

COPD: Optimizing Treatment [PDF]

, 2015
A guideline update and an expanded armamentarium have many physicians wondering how best to treat patients with COPD. Chronic obstructive pulmonary disease (COPD) carries a high disease burden. In 2012, it was the 4th leading cause of death worldwide.1,2
Ahmed-Sarwar, Nabila, Holub, David C, Pierce, Deirdre P   +2 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

tiRNA-Val promotes angiogenesis via Sirt1–Hif-1α axis in mice with diabetic retinopathy

Biological Research, 2022
Background Diabetic retinopathy (DR) is a specific microvascular complication arising from diabetes, and its pathogenesis is not completely understood.
Yan Xu, Haidong Zou, Qi Ding, Yuelan Zou, Chun Tang, Yuyu Lu, Xun Xu   +6 more
doaj   +1 more source

New surgical treatment for nonneoplastic tracheoesophageal fistula

Бюллетень сибирской медицины, 2012
Original method of nonneoplastic tracheoesophageal fistula disjunction using compression construction with shape memory has been developed. The experimental study was performed on mongrels with preliminarily made tracheoesophageal fistula.
Ye. B. Topolnitsky, G.New surgical treatment for nonneoplast Ts. Dambayev   +1 more
doaj   +1 more source

Adjunctive Use of Calcipotriene/Betamethasone Dipropionate Foam in a Real-World Setting Curtails the Cost of Biologics Without Reducing Efficacy in Psoriasis

Dermatology and Therapy, 2020
Introduction Although the efficacy of monotherapy with biologics for psoriasis is well established, many patients fail to achieve complete plaque clearance from their initial biologic treatment alone.
Jerry Bagel, Elise Nelson, James Zapata, Alexa Hetzel   +3 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source