Results 141 to 150 of about 23,655,214 (287)

Estimating Heterogeneity in the Benefits of Medical Treatment Intensity [PDF]

Federal and state laws passed in the late 1990 increased considerably postpartum stays for newborns. Using all births in California over the 1995-2001 period, 2SLS estimates suggest that for the average newborn impacted by the law, increased treatment ...
Craig L. Garthwaite, William N. Evans
core  

Localization of Early Treatment Effects From Magnetic Resonance Imaging of the Wrist, Hand, and Foot of Patients With Arthralgia at Risk for Rheumatoid Arthritis

IEEE Access
Determining the response to early treatment of arthralgia patients suspected of developing Rheumatoid Arthritis (RA) in a randomized placebo-controlled trial, requires sensitive and specific biomarkers of inflammation, in which Magnetic Resonance Imaging
Jingnan Jia, Tahereh Hassanzadeh, Yanli Li, Denis P. Shamonin, Dennis A. Ton, M. Els Bakker, Monique Reijnierse, Annette H. M. van der Helm-van Mil, Berend C. Stoel   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Assessment of atmospheric plasma treatment cleaning effect on steel surfaces

, 2013
Financial support from the BSH Electrodomésticos España S.A., the Fundación Universidad Carlos III de Madrid and the Instituto Tecnológico de Química y Materiales “Álvaro Alonso Barba” is acknowledged.
Martínez, Miguel Ángel, Encinas García, Noemí, Rodríguez-Villanueva, Carlos, Abenojar, Juana   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Selection of Control Variables in Propensity Score Matching: Evidence from a Simulation Study [PDF]

Propensity score matching is a widely-used method to measure the effect of a treatment in social as well as health sciences. An important issue in propensity score matching is how to select conditioning variables in estimation of the propensity score. It
Nguyen Viet, Cuong
core  

Medical Insurance Reimbursement and the Effects of Tuberculosis Management in Guangxi Province, China: A Retrospective Cross-Sectional Study

Risk Management and Healthcare Policy
Aimei Liu,1,2,* Sang Liu,1,2,* Peijiang Pan,3,* Yanyan Liao,3 Junli Huang,2 Yucheng Tang,2 Li Ye,3,4 Hao Liang3,4 1Department of Infectious Diseases, Chest Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, Guangxi, People’s Republic of ...
Liu A, Liu S, Pan P, Liao Y, Huang J, Tang Y, Ye L, Liang H   +7 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source