Results 151 to 160 of about 8,931,330 (313)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Natural history of intestinal failure, investigated through a network-based approach.

, 2003
OBJECTIVES: Intestinal failure (IF) is a condition whose treatment requires advanced knowledge and techniques and a multidisciplinary approach. Intestinal failure is the endpoint of many intestinal diseases and may result in full recovery, in life-long ...
DE MARCO G, FOR THE ITALIAN NATIONAL NETWORK FOR PEDIATRIC INTESTINAL FAILURE, GUARINO, ALFREDO   +2 more
core   +1 more source

Corrigendum: Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study

Frontiers in Nutrition, 2023
Ming Kong, Ning Lin, Lili Wang, Nan Geng, Manman Xu, Shanshan Li, Wenyan Song, Ying Zhou, Yuetong Piao, Zuoqing Han, Rong Guo, Chao Yang, Nan Luo, Zhong Wang, Quanxiao Xu, Daimeng Shi, Wanchun Qiu, Junfeng Li, Eddie C. Cheung, Eddie C. Cheung, Lei Ma, Yu Chen, Zhongping Duan   +22 more
doaj   +1 more source

Africa cannot afford to wait for malaria treatment failure. [PDF]

Malariaworld J
Pindolia D, Martinez-Vega R, Uzakbayeva G, Ishengoma D, Ngou O, Gosling R.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Post-scabies Dermatitis Mimicking Treatment Failure: A Diagnostic Challenge. [PDF]

Cureus
Saleh SM, Azzam R.
europepmc   +1 more source

Immunological Treatment of Implantation Failure

Annals of the New York Academy of Sciences, 1991
DE PLACIDO G, ZULLO F, COLACURCI, Nicola, PERRONE D, NAZZARO A, PAOLILLO F, MONTEMAGNO U.   +6 more
openaire   +5 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Factors associated with Human Immunodeficiency Virus first line treatment failure in Zvishavane District, Midlands Province, 2014

, 2019
Globally, first line HIV treatment failure remains a challenge particularly in resource constrained settings. Midlands Province 2013 data showed that Zvishavane district had the highest prevalence of first line treatment failure at 16% against a national
Matare, Takura
core  

Treatment failure in suspected community-acquired pneumonia revealing a pulmonary abscess. [PDF]

SAGE Open Med Case Rep
Earagolla S, Karnath N, Borra S, Karnath B.   +3 more
europepmc   +1 more source