Results 131 to 140 of about 31,464 (260)

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Non-invasive model for predicting future lung metastasis of hepatocellular carcinoma based on imaging heterogeneity analysis. [PDF]

Cancer Imaging
Wu H, Yang Y, Chen Y, Liao Z, Zhao W, Luo G, Tang K, Jiang Y, Li Q, Jia Z, Pan M, Huang W, Fu S, Duan C, Chen L.   +14 more
europepmc   +1 more source

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Rare but severe adverse events (AEs) associated with mRNA‐lipid nanoparticle (LNP) COVID‐19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these phenomena.
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész, Tamás Mészáros, Bálint A. Barta, Réka Facsko, Anna Szilasi, Tamás Bakos, Gergely T. Kozma, Attila B. Dobos, Béla Merkely, Tamás Radovits, János Szebeni   +13 more
wiley   +1 more source

Nanoparticles synthesis, properties and promising devices for drug delivery systems: a review. [PDF]

Discov Nano
Barai M.
europepmc   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

British Journal of Pharmacology, EarlyView.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam, James Harris, Jürgen Bernhagen, Antony Vinh, Katrina M. Mirabito Colafella   +4 more
wiley   +1 more source

Repurposing ALK inhibitors as influenza and corona virus antivirals targeting lymphocyte tyrosine kinase (LTK). [PDF]

Virus Res
Tjärnhage E, Våtsveen TK, Raki M, Nemazee D, Farhan H, Munthe L, Grodeland G.   +6 more
europepmc   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Non-Thermal Plasma Technologies for Plant Virus Inactivation: Sources, Mechanisms, and Practical Applications. [PDF]

Plant Pathol J
Park MR, Kim MJ, Cho SY, Jeong RD.
europepmc   +1 more source

Significance of Systemic Immune‐Inflammation and Inflammatory Response Indices in Vestibular Neuritis

Clinical Otolaryngology, EarlyView.
ABSTRACT Introduction This study investigated the relationship between vestibular neuritis and various systemic inflammatory indices—namely, neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), monocyte‐to‐lymphocyte ratio (MLR), systemic immune‐inflammation index (SII), and systemic inflammation response index (SIRI) and the ...
Tuğba Tulacı, Mustafa Utku Akbaş, Hasan Çanakçı, Tarık Yetişir, Kamil Gökçe Tulacı, Haşmet Yazıcı, Gulendam Kayıkçı, Omer Hizli   +7 more
wiley   +1 more source

Clinical characteristics and risk factors associated with mortality in hospitalized patients with COVID-19 aged 90 years or older. [PDF]

Medicine (Baltimore)
Wu M, Yin Q, Cao Y, Zheng K, Cai J, Wang W, Hu Y, Guan H, Ren Q, Zhu H, Lan X, Zhu W.   +11 more
europepmc   +1 more source