Results 101 to 110 of about 17,612,218 (346)

A randomized trial of intraarterial treatment for acute ischemic stroke.

New England Journal of Medicine, 2015
BACKGROUND In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of a beneficial effect on functional outcome is lacking.
O. Berkhemer, P. Fransen, D. Beumer, Lucie A van den Berg, Hester F. Lingsma, A. Yoo, W. Schonewille, J. Vos, P. Nederkoorn, M. Wermer, M. V. van Walderveen, J. Staals, J. Hofmeijer, J. V. van Oostayen, G. J. Lycklama à Nijeholt, J. Boiten, P. Brouwer, B. Emmer, S. D. de Bruijn, L. V. van Dijk, L. Kappelle, Rob H. Lo, E. V. van Dijk, J. de Vries, P. D. de Kort, W. V. van Rooij, J. V. D. van den Berg, B. V. van Hasselt, L. Aerden, R. Dallinga, M. Visser, J. Bot, P. Vroomen, O. Eshghi, T. Schreuder, R. Heijboer, K. Keizer, A. Tielbeek, H. D. den Hertog, D. Gerrits, R. M. Van den Berg-Vos, G. Karas, E. Steyerberg, H. Z. Flach, H. Marquering, M. Sprengers, S. Jenniskens, L. Beenen, R. van den Berg, P. Koudstaal, W. V. van Zwam, Y. Roos, A. van der Lugt, R. V. van Oostenbrugge, C. Majoie, D. Dippel   +55 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

MSI as a predictive factor for treatment outcome of gastroesophageal adenocarcinoma.

Cancer Treatment Reviews, 2020
M. Velzen, S. Derks, N. Grieken, N. H. Mohammad, H. Laarhoven   +4 more
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Peptic Ulcer in the British Army: A Comparison of Outcome following Medical and Early or Late Surgical Treatment in the Pre-Cimetidine Era [PDF]

, 1979
Darren M. Roberts, David Messent
openalex   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Latest Research Trends on the Management of Hemorrhoids

Journal of the Anus, Rectum and Colon
Hemorrhoids manifest with a range of symptoms and severities, prompting the development of various conservative, interventional, and surgical treatments.
Sung Il Kang
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source