Results 181 to 190 of about 19,267,272 (276)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Placement of metallic stents for treatment of postoperative biliary strictures: long-term outcome in 25 patients.

, 1997
D Bonnel, C Liguory, J Lefebvre, F. Cornud   +3 more
openalex   +1 more source

The influence of HLA‐matched sibling donor availability on treatment outcome for patients with AML: an analysis of the AML 8A study of the EORTC Leukaemia Cooperative Group and GIMEMA [PDF]

, 1998
S. Keating, Théo de Witte, Stefan Suciu, Roel Willemze, Marcel Hayat, Boris Labar, L Resegotti, Pierluigi Rossi Ferrini, Francesco Paolo Caronia, M Dardenne, G. Solbu, M. C. Petti, M. L. Vegna, F Mandelli, R Zittoun   +14 more
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Feared consequences, fixity of belief, and treatment outcome in patients with obsessive-compulsive disorder

, 1999
Edna B. Foa, Jonathan S. Abramowitz, Martin E. Franklin, Michael J. Kozak   +3 more
openalex   +1 more source

The national diabetic retinopathy laser treatment audit III. Clinical outcomes [PDF]

, 1999
Clare Bailey, J M Sparrow, R H Grey, H Cheng   +3 more
openalex   +1 more source

Dissociated response and treatment outcome with immune checkpoint blockade in advanced cancer. [PDF]

Sci Rep
Guan Y, Cui Y, Gong Y, Liang X, Han X, Chen Y, Xie H, Zhang Y, Wang B, Ye X, Wang J.   +10 more
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Impact of new treatments for respiratory failure on outcome of infants with congenital diaphragmatic hernia [PDF]

, 1999
Marco Somaschini, G. Locatelli, L. Salvoni, Cristina Bellan, Riccardo Colombo   +4 more
openalex   +1 more source

Influence of apical patency in endodontic treatment outcome - A systematic review of clinical studies. [PDF]

J Conserv Dent Endod
Kuzhanchinathan M, Dhakshinamurthi B, Rajendran MR, Kalaiselvam R.   +3 more
europepmc   +1 more source