Results 261 to 270 of about 17,612,218 (346)

Subtle changes on electrocardiogram in severe patients with COVID-19 may be predictors of treatment outcome. [PDF]

Front Artif Intell
Chaikovsky I, Dziuba D, Kryvova O, Marushko K, Vakulenko J, Malakhov K, Loskutov О.   +6 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Dehydrothyrsiferol Against Cutaneous Leishmaniasis: Treatment Outcome in a Murine Model. [PDF]

Mar Drugs
López-Arencibia A, Bethencourt-Estrella CJ, San Nicolás-Hernández D, Rodríguez-Expósito RL, Domínguez-de-Barros A, Salazar-Villatoro L, Omaña-Molina M, Cen-Pacheco F, Díaz-Marrero AR, Fernández JJ, Córdoba-Lanús E, Lorenzo-Morales J, Piñero JE.   +12 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Prognostic factors of progesterone resistance in symptomatic adenomyosis: impact of lesion localization on treatment outcome of levonorgestrel intrauterine system. [PDF]

BMC Womens Health
Hiratsuka D, Matsuo M, Ishizawa C, Fukui Y, Hiraoka T, Aikawa S, Izumi G, Harada M, Wada-Hiraike O, Osuga Y, Hirota Y.   +10 more
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Treatment outcome and determinant factors of bacterial meningitis at pediatric ward: a multicenter study from Northwest Ethiopia. [PDF]

Sci Rep
Siraj EA, Tebikew M, Abay H, Kebede SY, Tafere C, Bahiru B, Demsie DG, Gizachew B, Bizuneh GK, Motbaynor G, Yismaw MB, Agmassie Z, Yayehrad AT, Addisu ZD.   +13 more
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Long-Term Treatment Outcome and Recidivism Patterns Among Intimate Partner Violence Perpetrator Typology: A 15-Year Follow-Up Study. [PDF]

Clin Psychol Psychother
Redondo N, Ronzón-Tirado R, Muñoz-Rivas MJ, Graña JL.   +3 more
europepmc   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source