Results 21 to 30 of about 19,267,272 (276)

Messages for Clinicians: Moderators and Mediators of Treatment Outcome in Randomized Clinical Trials.

American Journal of Psychiatry, 2016
Many problems in randomized clinical trial design, execution, analysis, presentation and interpretation stem in part from an inadequate understanding of the roles of moderators and mediators of treatment outcome.
H. Kraemer
semanticscholar   +1 more source

Expressed Emotion, Family Functioning, and Treatment Outcome for Adolescents with Anorexia Nervosa.

European eating disorders review, 2016
The current study examined the relation between parental expressed emotion (EE) and treatment outcome among adolescents participating in a treatment study for adolescent anorexia nervosa, as well as its impact on family functioning.
Renee D. Rienecke, Erin C. Accurso, J. Lock, D. Le Grange   +3 more
semanticscholar   +1 more source

Remdesivir for the Treatment of Covid-19 — Final Report

New England Journal of Medicine, 2020
Background Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious.
J. Beigel, K. Tomashek, L. Dodd, A. Mehta, B. Zingman, A. Kalil, E. Hohmann, H. Chu, A. Luetkemeyer, S. Kline, Diego López de Castilla, R. Finberg, K. Dierberg, V. Tapson, L. Hsieh, T. Patterson, R. Paredes, D. Sweeney, W. Short, G. Touloumi, D. Lye, N. Ohmagari, M. Oh, G. Ruiz-Palacios, T. Benfield, G. Fätkenheuer, M. Kortepeter, R. Atmar, C. Creech, J. Lundgren, A. Babiker, S. Pett, J. Neaton, T. Burgess, Tyler Bonnett, Michelle Green, M. Makowski, A. Osinusi, S. Nayak, H. Lane   +39 more
semanticscholar   +1 more source

Evaluating the origin and spread of spotted lanternfly (Lycorma delicatula) in Japan

Population Ecology, EarlyView.
The invasive spotted lanternfly (Lycorma delicatula) is native to China and is a serious economic pest in the Republic of Korea and the United States, though it is not considered a pest in Japan. We established a distribution map of L. delicatula in Japan through a comprehensive review of published literature and citizen science reports and analyzed ...
Matthew T. Kamiyama, Michihiko Takahashi, Hannah J. Broadley, Francesc Gómez‐Marco, Mark S. Hoddle, Kenji Matsuura   +5 more
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Defining Early Positive Response to Psychotherapy: An Empirical Comparison Between Clinically Significant Change Criteria and Growth Mixture Modeling [PDF]

, 2015
Several different approaches have been applied to identify early positive change in response to psychotherapy so as to predict later treatment outcome and length as well as use this information for outcome monitoring and treatment planning. In this study,
Kopta, Stephen mark, Köck, Katharina, Lutz, Wolfgang, Minami, Takuya, Rubel, Julian, Saunders, Stephen M., Zimmermann, Dirk   +6 more
core   +1 more source

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C [PDF]

, 2012
Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C.
Badenhoop, Klaus, Berg, Thomas, Bibert, Stephanie, Bochud, Pierre-Yves, Bojunga, Jörg, Burgisser, Philippe, Cerny, Andreas, Dufour, Jean-François, Geier, Andreas, Gerlach, Tilman J, Heim, Markus H, Kutalik, Zoltan, Lange, Christian M, Malinverni, Raffaele, Moradpour, Darius, Müller, Tobias, Negro, Francesco, Regenass, Stephan, Sarrazin, Christoph, Swiss Hepatitis C Cohort Study Group,, Zeuzem, Stefan   +20 more
core   +4 more sources

Specific gyrA gene mutations predict poor treatment outcome in MDR-TB

Journal of Antimicrobial Chemotherapy, 2015
Objectives Mutations in the gyrase genes cause fluoroquinolone resistance in Mycobacterium tuberculosis. However, the predictive value of these markers for clinical outcomes in patients with MDR-TB is unknown to date.
L. Rigouts, L. Rigouts, N. Coeck, N. Coeck, M. Gumusboga, W. B. D. Rijk, K. J. Aung, M. Hossain, K. Fissette, H. Rieder, C. Meehan, B. Jong, B. Jong, B. Jong, A. Deun, A. Deun   +15 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source