Results 151 to 160 of about 8,995,986 (306)

Policy issues for the Community Development Employment Projects scheme in rural and remote Australia [PDF]

One of the most important programs for Indigenous community and economic development is the Community Development Employment Projects (CDEP) scheme. CDEP employs around 35,000 Indigenous Australians and accounts for over one-quarter of total Indigenous ...
Levitus, Robert, Gray, Matthew, Altman, Jon   +2 more
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Research and Application of Heat Treatment Process with 20Cr13 Martensitic Stainless Steel Material for Chain

Jixie chuandong, 2016
View of the fracture problem of the chain in the 20Cr13 material of martensitic stainless steel,the scheme of improving the heat treatment process is put forward.
Zhang Jiancong, Wang Lili, Huang Jia
doaj  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

COMPARATIVE ASPECTS OF LAMBLIOSIS TREATMENT SCHEMES [PDF]

International Journal of Applied and Fundamental Research (Международный журнал прикладных и фундаментальных исследований), 2019
R.Kh. Begaydarova, S.M. Adekenov, K.A. Yukhnevich, G.K. Alshynbekova, G.E. Nasakaeva, A.E. Dyusembaeva, O.A. Zolotareva   +6 more
openaire   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Efficacy and safety of a novel treatment scheme of RC48-ADC plus PD-1 inhibitors in metastatic urothelial carcinoma: a multicenter real-world study. [PDF]

Ther Adv Med Oncol
Lin J, Bai J, Li X, Wen Y, Ye Y, Chen S, Chen H, Qiu Q, Huang J, Ye Y, Liu R, Kang D, Chen R, Lu Q, Su Y, Zhang W, Wei Y, Zhu S, Chen J.   +18 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Streamlining scheme theory with topoi [PDF]

openA course in scheme theory entirely from the internal perspective of the sheaf topos: The thesis presents the concepts of topoi ane how to work with the internal logic of a topos, and then follows the guidelines of Hartshorne's "Algebraic Geometry ...
TOGNETTI, FRANCESCO
core