Results 131 to 140 of about 8,995,986 (306)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Treatment of late bacterial infections resulting from soft-tissue filler injections

Infection and Drug Resistance, 2019
Wojciech Marusza,1 Romuald Olszanski,2 Janusz Sierdzinski,3 Tomasz Ostrowski,4 Kamila Szyller,1 Grazyna Mlynarczyk,5 Irina Netsvyetayeva5 1Academy of Face Sculpting, Warsaw, Poland; 2Military Institute of Health Services, Warsaw, Poland; 3Department of ...
Marusza W, Olszanski R, Sierdzinski J, Ostrowski T, Szyller K, Mlynarczyk G, Netsvyetayeva I   +6 more
doaj  

Empowering wastewater treatment with step scheme heterojunction ternary nanocomposites for photocatalytic degradation of nitrophenol

Scientific Reports
The ongoing challenge of water pollution necessitates innovative approaches to remove organic contaminants from wastewater. In this work, new two-dimensional S-scheme heterojunction photocatalysts Bi2O3/CdS and MoS2/Bi2O3/CdS that are intended for the ...
Zhu Liu, Mah Roosh, Ming Lu, Aqsa Arshad, Wenqi Xian, Yuqiu Shen, Guocong Liu, Ali Bahadur, Shahid Iqbal, Sajid Mahmood, Khalid M. Alotaibi   +10 more
doaj   +1 more source

Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival. [PDF]

Hematol Transfus Cell Ther, 2020
Jaime-Pérez JC, Santos JAHL, Gómez-Almaguer D.   +2 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Scheme Pearl: Quantum Continuations

We advance the thesis that the simulation of quantum circuits is fundamentally about the efficient management of a large (potentially exponential) number of delimited continuations.
Choudhury, Vikraman, Sabry, Amr, Agapiev, Borislav   +2 more
core   +4 more sources

Analytical Approximation for Non-linear FBSDEs with Perturbation Scheme [PDF]

In this work, we have presented a simple analytical approximation scheme for generic non-linear FBSDEs. By treating the interested system as the linear decoupled FBSDE perturbed with non-linear generator and feedback terms, we have shown that it is ...
Masaaki Fujii, Akihiko Takahashi
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Building Treatment and Its Effects on City‐Scale Urban Flood Modeling

Journal of Flood Risk Management
Physics‐based flood hydrodynamic models are widely used for predicting inundation in urban basins with complex building layouts. While the treatment of urban buildings in these models has been extensively discussed, over‐assumptions can introduce ...
Zekai Li, Kaihua Guo, Huanfeng Duan, Mingfu Guan   +3 more
doaj   +1 more source