Results 301 to 310 of about 14,986,124 (359)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

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Why Study Treatment Outcome?

Psychiatric Services, 1991
Concern about the spiraling cost of mental health care has increased the need for reliable data about the outcomes of such care. Treatment outcome studies, although difficult to design and carry out, are essential in demonstrating the efficacy of psychiatric treatment, rationalizing clinical decision making, and encouraging public support for the ...
S M, Mirin, M J, Namerow
openaire   +2 more sources

ICR treatment studies

Journal AWWA, 1998
Utilities are currently evaluating membranes and GAC for DBP precursor removal.Under the treatment study requirement of the Information Collection Rule, 493 treatment plants were required to monitor total organic carbon (TOC) concentrations in their influent or finished water to determine whether studies evaluating granular activated carbon or ...
Steven C. Allgeier, Hiba M. Shukairy, James J. Westrick   +2 more
openaire   +1 more source

Amblyopia treatment studies

Current Opinion in Ophthalmology, 2004
Amblyopia continues to be a major cause of vision loss in children. Several different treatment modalities exist. Research in the field of amblyopia has been very active over the past few years, and clinical practice patterns are changing.Atropine has been found to be effective in the treatment of amblyopia.
openaire   +2 more sources

MS treatment: Postmarketing studies

Journal of the Neurological Sciences, 2007
Multiple sclerosis (MS) is an inflammatory chronic demyelinating disease. Nowadays, there are several registered drugs aimed to control the disease activity. Because these drugs are given parenterally for years, it is of utmost importance to attain maximum adherence to treatment through close and permanent care of patients.
openaire   +2 more sources

Ocular Hypertension Treatment Study

Journal of Glaucoma, 1993
This report relates the design and conduct considerations in the planning of a large, multicenter clinical trial on the treatment of ocular hypertension. This trial will begin patient enrollment in January 1994.
M O, Gordon, M A, Kass
openaire   +2 more sources

REFLEX STUDIES IN ELECTROSHOCK TREATMENTS

Archives of Neurology And Psychiatry, 1948
administration of extramural electroshock therapy, special attention was paid to the problem of reflex changes following treatments. Various investigators have repeatedly pointed out the frequent presence of tendon hyperrflexia, ankle clonus and a Babinski sign following electroshock convulsions. Kino1 alone noted frequent plantar areflexia for a short
N, SAVITSKY, W, KARLINER
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The Mental Health Treatment Study.

Psychiatric Rehabilitation Journal, 2008
Security Disability Insurance (SSDI) beneficiaries with primary psychiatric impairments comprise the largest, fastest growing, and most costly population in the SSDI program. The Mental Health Treatment Study provides a comprehensive test of the hypothesis that access to evidence-based employment services and behavioral health treatments, along with ...
William D, Frey, Susan T, Azrin, Howard H, Goldman, Susan, Kalasunas, David S, Salkever, Alexander L, Miller, Gary R, Bond, Robert E, Drake   +7 more
openaire   +2 more sources

Exocrine pancreatic insufficiency treatment study

Veterinary Record, 2009
Exocrine pancreatic insufficiency (EPI) is a common condition in dogs, with early response to therapy being critical for positive outcomes ([Batchelor and others 2007][1]). Pancreatic enzyme supplementation is the key component of therapy in EPI. Numerous enzyme preparations exist for use in dogs,
Aran, Mas, P-J M, Noble, A J, German
openaire   +2 more sources