Results 31 to 40 of about 83,957 (266)

GbTRB1 binds telomeric DNA in Ginkgo biloba

BMC Plant Biology
Telomere-binding proteins play a crucial role in maintaining the stability of telomere structures. In this study, we found that GbTRB1, a double-stranded telomere-binding protein, can bind telomeric DNA., plays a pivotal role in telomere complex ...
Yu Sun, Huimin Zhang, Yirong Zou, Xueqin Guo, Yuping Feng, Di Liu, Hai Lu   +6 more
doaj   +1 more source

Genome-wide identification and analysis of class III peroxidases in Betula pendula

BMC Genomics, 2021
Background Class III peroxidases (POD) proteins are widely present in the plant kingdom that are involved in a broad range of physiological processes including stress responses and lignin polymerization throughout the plant life cycle.
Kewei Cai, Huixin Liu, Song Chen, Yi Liu, Xiyang Zhao, Su Chen   +5 more
doaj   +1 more source

Seasonal Changes in Soil Microbial Community and Co-Occurrence Network of Species of the Genus Corylus

Microorganisms, 2021
Hazelnut is one of the four major nuts in the world and has high nutritional and economic value. This study employed Illumina sequencing of ITS rDNA and 16S rRNA genes to identify the seasonal changes in soil microbial community, the predominant ...
Wenxu Ma, Zhen Yang, Lisong Liang, Qinghua Ma, Guixi Wang, Tiantian Zhao   +5 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Drought tolerance evaluation of Fraxinus mandshurica in a semi-arid area

BMC Plant Biology
Background Fraxinus mandshurica Rupr. is a key forest species in Northeast Asia, primarily distributed in semi-humid regions. Given its wide range of provenances, F. mandshurica exhibits substantial genetic and phenotypic variations.
Kaifang Zhang, Yuan Cao, Xinyue Guo, Xiaonuo Liu, Qing Li, Fanqiu Kong, Fansuo Zeng, Tianzhong Jing, Yaguang Zhan, Fenghui Qi   +9 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Integrated transcriptomic and WGCNA identify drought-responsive TFs in Larix olgensis

BMC Plant Biology
Global forests face increasingly severe drought events, which suppress the growth of larch. Transcription factors (TFs), acting as regulators, can increase plant stress tolerance by modulating gene expression networks.
Wenna Zhao, Hao Dong, Chengpeng Cui, Chen Wang, Yu Liu, Yajing Ning, Hanguo Zhang, Meng Li, Shujuan Li   +8 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Synergistic optimization enhancing the precision and efficiency of cytosine base editors in poplar

Communications Biology
CRISPR/Cas9 genome editing technology, particularly cytosine base editing (CBE) systems, emerges as a powerful tool for precise genomic modification in plants, offering transformative applications across agricultural and forestry research and breeding ...
Han Liu, Mengyu Zhang, Leiqian Sun, Yu Peng, Yu Sun, Yawei Fan, Hui Li, Di Liu, Hai Lu   +8 more
doaj   +1 more source