Results 41 to 50 of about 313,592 (358)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Drought tolerance evaluation of Fraxinus mandshurica in a semi-arid area

BMC Plant Biology
Background Fraxinus mandshurica Rupr. is a key forest species in Northeast Asia, primarily distributed in semi-humid regions. Given its wide range of provenances, F. mandshurica exhibits substantial genetic and phenotypic variations.
Kaifang Zhang, Yuan Cao, Xinyue Guo, Xiaonuo Liu, Qing Li, Fanqiu Kong, Fansuo Zeng, Tianzhong Jing, Yaguang Zhan, Fenghui Qi   +9 more
doaj   +1 more source

TCP Transcription Factors Involved in Shoot Development of Ma Bamboo (Dendrocalamus latiflorus Munro)

Frontiers in Plant Science, 2022
Ma bamboo (Dendrocalamus latiflorus Munro) is the most widely cultivated clumping bamboo in Southern China and is valuable for both consumption and wood production.
Kangming Jin, Kangming Jin, Yujun Wang, Renying Zhuo, Jing Xu, Zhuchou Lu, Huijin Fan, Biyun Huang, Guirong Qiao   +8 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Synergistic optimization enhancing the precision and efficiency of cytosine base editors in poplar

Communications Biology
CRISPR/Cas9 genome editing technology, particularly cytosine base editing (CBE) systems, emerges as a powerful tool for precise genomic modification in plants, offering transformative applications across agricultural and forestry research and breeding ...
Han Liu, Mengyu Zhang, Leiqian Sun, Yu Peng, Yu Sun, Yawei Fan, Hui Li, Di Liu, Hai Lu   +8 more
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Integrated transcriptomic and WGCNA identify drought-responsive TFs in Larix olgensis

BMC Plant Biology
Global forests face increasingly severe drought events, which suppress the growth of larch. Transcription factors (TFs), acting as regulators, can increase plant stress tolerance by modulating gene expression networks.
Wenna Zhao, Hao Dong, Chengpeng Cui, Chen Wang, Yu Liu, Yajing Ning, Hanguo Zhang, Meng Li, Shujuan Li   +8 more
doaj   +1 more source

Modelling of selection and mating decisions in tree breeding programs [PDF]

, 1996
Hardwood trees from the temperate forests of southern Australia are an important source of timber for high quality paper. Two species in particular, Eucalyptus globulus and Eucalyptus nitens are well suited to this purpose and are now widely grown in ...
Howlett, P., Thompson, C.
core  

Lignin engineering in forest trees [PDF]

, 2019
Wood is a renewable resource that is mainly composed of lignin and cell wall polysaccharides. The polysaccharide fraction is valuable as it can be converted into pulp and paper, or into fermentable sugars.
Alvarenga Chanoca, Alexandra, Boerjan, Wout, de Vries, Lisanne   +2 more
core   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source