Results 71 to 80 of about 300,695 (305)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Modeling Moso Bamboo Tree Density and Aboveground Biomass Using Multi-Site UAV-LiDAR Data

Remote Sensing
Moso bamboo, widely distributed in subtropical regions of China, plays an important role in forest management and carbon cycle research. However, accurate estimation of tree density and aboveground biomass (AGB) remains challenging due to the unique ...
Xinyao Liu, Guiying Li, Longwei Li, Dengsheng Lu   +3 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Tropical Density Estimation of Phylogenetic Trees

IEEE/ACM Transactions on Computational Biology and Bioinformatics
18 ...
Ruriko Yoshida, David Barnhill, Keiji Miura, Daniel K. Howe   +3 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Mapping the density of giant trees in the Amazon

New Phytologist
Summary Tall trees (height ≥ 60 m) are keystone elements of tropical forests, strongly influencing biodiversity, carbon storage, and ecosystem resilience. Yet, their density and spatial distribution remain poorly quantified, especially in remote Amazonian regions ...
de Lima, RB, da Silva, DAS, Nunes, MH, Bittencourt, PRDL, Groenendyk, P, de Oliveira, CP, Granato‐Souza, D, Caraciolo Ferreira, RL, Aleixo da Silva, JA, Aguirre‐Gutiérrez, J, Jackson, T, de Matos Filho, JR, Aparício, PDS, da Silva, JPG, de Toledo, JJ, Guedes, MC, de Almeida, DRA, Higuchi, N, Wagner, FH, Ometto, JP, Görgens, EB   +20 more
openaire   +4 more sources

Carbon Sequestration Potential of Agroforestry versus Adjoining Forests at Different Altitudes in the Garhwal Himalayas

Atmosphere
Forests face a variety of threats in the modern era. Agroforestry systems, both traditional and introduced, have a tremendous capacity for providing sustainable resources and combating the impact of global climate change.
Naresh Singh, Manoj Kumar Riyal, Bhupendra Singh, Vinod Prasad Khanduri, Deepa Rawat, Chandramohan Singh, Marina M. S. Cabral Pinto, Munesh Kumar   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Wood density and microfibril angle from pith to bark of a sugi cultivar (Cryptomeria japonica, Japanese cedar, Tosaaka) grown in a Nelder plot

Journal of Wood Science, 2022
The current stumpage price in harvesting of a 50-year-old sugi (Japanese cedar, Cryptomeria japonica) plantation is not enough to motivate forest owners to reforest. Therefore, it is vital to reduce the cost for reforestation after logging as well as for
Yoshio Kijidani, Taku Tsuyama, Hisato Oda, Ryoko Hirata, Satoshi Ito   +4 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source