Results 61 to 70 of about 300,695 (305)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

density-matching v1.0

, 2015
Codes for density-matching, a new approach for optimization under ...
Pranay Seshadri
core   +1 more source

Effect of diurnal solar radiation regime and tree density on sap flow of Norway spruce (Picea abies [L.] Karst.) in fragmented stand

Central European Forestry Journal
The continuous threat of ongoing climate change and related weather anomalies challenge forest ecosystems. The phytosociological structure of forests plays a crucial role in determining their resilience to various abiotic and biotic stressors ...
Singh Vivek Vikram, Zabihi Khodabakhsh, Trubin Aleksei, Cudlín Pavel, Korolyova Nataliya, Jakuš Rastislav, Blaženec Miroslav   +6 more
doaj   +1 more source

Assessing soil fertility index under different forest land cover

Sains Tanah: Journal of Soil Science and Agroclimatology
Soil fertility is often evaluated under various forest land cover types to determine the capacity of each area to support plant productivity. Therefore, this study aimed to (1) assess the current soil fertility status of six land cover types in the Alas ...
Widyatmani Sih Dewi, Purwanto Purwanto, Siti Solikhatun Anisa, Sri Hartati   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Revising midlatitude summer temperatures back to A.D. 600 based on a wood density network

, 2015
Annually resolved and millennium-long reconstructions of large-scale temperature variability are primarily composed of tree ring width (TRW) chronologies.
Esper, J., Jan Esper, Schneider, Lea, Ulf Büntgen, Schneider, L., Alexander V. Kirdyanov, Lea Schneider, Smerdon, J.E., Büntgen, U., Esper, Jan, Kirdyanov, Alexander V., Myglan, V.S., Smerdon, Jason E., Büntgen, Ulf, Wilson, Rob J., Wilson, R.J.S., Jason E. Smerdon, Rob J. S. Wilson, Kirdyanov, A.V., Myglan, Vladimir S., Vladimir S. Myglan   +20 more
core   +1 more source

Use of UAV Photogrammetric Data for Estimation of Biophysical Properties in Forest Stands Under Regeneration

Remote Sensing, 2019
The objective of this study was to assess the use of unmanned aerial vehicle (UAV) data for modelling tree density and canopy height in young boreal forests stands.
Stefano Puliti, Svein Solberg, Aksel Granhus   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

carolineramoroso/host-density-transmission: Host density shapes transmission code

, 2022
Code that accompanies the manuscript Host density shapes the relative contribution of vector-based and aerial transmission of a pathogenic fungus Authors: Janis Antonovics, Caroline R. Amoroso, Emily Bruns, and Michael Hood.
carolineramoroso
core   +1 more source

Comparison of Microclimate Condition and Thermal Comfort Levels between Public and Private Green Open Space: A Case Study of Denggung Park and Gadjah Mada University Wisdom Park

Jurnal Ilmu Kehutanan
Rapid urban population growth has driven extensive economic, residential, educational, and cultural development, leading to the conversion of green spaces into built-up areas. This conversion interferes with the regulations of air temperature and Thermal
Abi Abdillah Niko Ghaniyy, Diah Fitri Astuti Ningrum   +1 more
doaj   +1 more source