Results 41 to 50 of about 162,405 (282)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The importance of drought–pathogen interactions in driving oak mortality events in the Ozark Border Region

Environmental Research Letters, 2018
Forests are expected to become more vulnerable to drought-induced tree mortality owing to rising temperatures and changing precipitation patterns that amplify drought lethality. There is a crucial knowledge gap regarding drought–pathogen interactions and
Jeffrey D Wood, Benjamin O Knapp, Rose-Marie Muzika, Michael C Stambaugh, Lianhong Gu   +4 more
doaj   +1 more source

Tree rings provide early warning signals of jack pine mortality across a moisture gradient in the southern boreal forest

, 2015
Recent declines in productivity and tree survival have been widely observed in boreal forests. We used early warning signals (EWS) in tree ring data to anticipate premature mortality in jack pine (Pinus banksiana) - an extensive and dominant species ...
J M Metsaranta, Metsaranta, J. M., J F Johnstone, Chun, K. P., K P Chun, Barr, A. G., Johnstone, J. F., A G Barr, Mamet, S. D., S D Mamet   +9 more
core   +1 more source

Tree mortality during drought

, 2023
Understanding the drivers and mechanisms of tree mortality during drought has significant implications for forest management, especially under the background of global climate change with increasing drought frequency and severity.
Yanjun Su (8435694), Qin Ma (13275555)
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Temperature response surfaces for mortality risk of tree species with future drought

Environmental Research Letters, 2017
Widespread, high levels of tree mortality, termed forest die-off, associated with drought and rising temperatures, are disrupting forests worldwide. Drought will likely become more frequent with climate change, but even without more frequent drought ...
Henry D Adams, Greg A Barron-Gafford, Rebecca L Minor, Alfonso A Gardea, Lisa Patrick Bentley, Darin J Law, David D Breshears, Nate G McDowell, Travis E Huxman   +8 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Spatial Pattern of Living Woody and Coarse Woody Debris in Warm-Temperate Broad-Leaved Secondary Forest in North China

Plants
The investigation into the spatial distribution of living woody (LWD) and coarse woody debris (CWD) within forests represents a fundamental methodology for probing the inherent mechanisms governing coexistence and mortality within forest ecosystems. Here,
Fang Ma, Shunzhong Wang, Weiguo Sang, Keming Ma   +3 more
doaj   +1 more source

NITROGEN CAN LIMIT OVERSTORY TREE GROWTH FOLLOWING EXTREME STAND DENSITY INCREASE IN A PONDEROSA PINE FOREST

, 2019
Extreme stand density increases have occurred in ponderosa pine forests throughout the western U.S. since the early 20th Century, with adverse implications for growth, physiological functioning, and mortality risk. Identifying primary stressors on large,
Marshall, L.A., Marshall, L. A., Falk, Donald A., Mcdowell, Nate G.   +3 more
core   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source