Results 181 to 190 of about 1,071,502 (272)

Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma

Advanced Science, EarlyView.
This study discovers that SIRT1, a hub gene involved in glucolipid metabolic conversion in colorectal carcinoma (CRC), stimulates CX3CL1 secretion in CRC cells by activating FOXO1. The CX3CL1‐CX3CR1 signaling promotes the differentiation of TCF7+ regulatory T cells (Tregs) into an enhanced immunosuppressive TNFRSF9+ Treg phenotype.
Ruiyang Zi, Xiang Zhao, Limei Liu, Yijie Wang, Rui Zhang, Zhiheng Bian, Haoran Jiang, Taorui Liu, Yixin Sun, Han Peng, Xuesong Wang, Fanghao Lu, Chao Zhang, Fan Zhang, Qing Qin, Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong   +18 more
wiley   +1 more source

Misspecification Strikes: ASTRAL can Mislead in the Presence of Hybridization, even for Nonanomalous Scenarios. [PDF]

Mol Biol Evol
Dinh V, Baños H.
europepmc   +1 more source

Interpretable Machine‐Learning and Big Data Mining to Predict the CO2 Separation in Polymer‐MOF Mixed Matrix Membranes

Advanced Science, EarlyView.
To explore the structure‐property relationships of MMM (Mixed Matrix Membranes), the big data mining is employed and a transfer learning model is trained for predicting and selecting the optimal MMM materials. It achieves fast computation for the separation of CO2 in MMM.
Hao Wan, Yue Fang, Min Hu, Shuya Guo, Zhiqiang Sui, Xiaoshan Huang, Zili Liu, Yue Zhao, Hong Liang, Yufang Wu, Hanyu Gao, Zhiwei Qiao   +11 more
wiley   +1 more source

"A mathematical theory of evolution": phylogenetic models dating back 100 years. [PDF]

Philos Trans R Soc Lond B Biol Sci
Rosenberg NA, Stadler T, Steel M.
europepmc   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Multi-Objective Power Supply Restoration in Distribution Networks Based on Graph Calculation and Information Collected by Multi-Source Sensors. [PDF]

Sensors (Basel)
Dang J, Zhang S, Wang Y, Yan Y, Jia R, Liu G.   +5 more
europepmc   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Status of the ΛCDM theory: supporting evidence and anomalies. [PDF]

Philos Trans A Math Phys Eng Sci
Peebles PJE.
europepmc   +1 more source

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Advanced Science, EarlyView.
A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielman, Regina Luttge, Jens C. Schwamborn   +14 more
wiley   +1 more source

Task Planning of Multiple Unmanned Aerial Vehicles Based on Minimum Cost and Maximum Flow. [PDF]

Sensors (Basel)
Shi X, Zhai X, Wang R, Le Y, Fu S, Liu N.   +5 more
europepmc   +1 more source