Results 41 to 50 of about 1,071,502 (272)

Data Mining and Analysis of the Compatibility Law of Traditional Chinese Medicines Based on FP-Growth Algorithm

Journal of Mathematics, 2021
The compatibility law of prescriptions is the core link of TCM theory of “theory, method, prescription and medicine,” which is of great significance for guiding clinical practice, new drug development and revealing the scientific connotation of TCM ...
Shuchun Zhou
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Building trees by juggling information and following rules: an expert interview study on tree-building and phylogenetic inference

Evolution: Education and Outreach
Tree-thinking is a fundamental skill set for understanding evolutionary theory and, thus, part of biological and scientific literacy. Research on this topic is mostly directed towards tree-reading—the umbrella-term for all skills enabling a person to ...
Steven Tyrrell, Philipp Schmiemann
doaj   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Synthesis of Deterministic Top-down Tree Transducers from Automatic Tree Relations [PDF]

EPTCS 161, 2014, pp. 88-101, 2014
We consider the synthesis of deterministic tree transducers from automaton definable specifications, given as binary relations, over finite trees. We consider the case of specifications that are deterministic top-down tree automatic, meaning the specification is recognizable by a deterministic top-down tree automaton that reads the two given trees ...
arxiv   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Uncertainty-Aware Dynamic Reliability Analysis Framework for Complex Systems

IEEE Access, 2018
Critical technological systems exhibit complex dynamic characteristics such as time-dependent behavior, functional dependencies among events, sequencing and priority of causes that may alter the effects of failure.
Sohag Kabir, Mohammad Yazdi, Jose Ignacio Aizpurua, Yiannis Papadopoulos   +3 more
doaj   +1 more source

Reliability analysis of station autonomous computer system based on fuzzy dynamic fault tree and Markov model

Engineering Reports, 2021
Station autonomous computer system is the core of the centralized traffic control (CTC) system. The working mode is dual computer hot standby, and its reliability is very important.
Lu Yan, Tao Zhang, Ying Gao, Rongsheng Wang, Shuxin Ding   +4 more
doaj   +1 more source

Weighted Regular Tree Grammars with Storage [PDF]

Discrete Mathematics & Theoretical Computer Science, Vol. 20 no. 1, Automata, Logic and Semantics (July 3, 2018) dmtcs:3664, 2017
We introduce weighted regular tree grammars with storage as combination of (a) regular tree grammars with storage and (b) weighted tree automata over multioperator monoids. Each weighted regular tree grammar with storage generates a weighted tree language, which is a mapping from the set of trees to the multioperator monoid.
arxiv   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source