Results 61 to 70 of about 276,476 (390)

Mitochondrial DNA disorders in neuromuscular diseases in diverse populations

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao, Katherine R Schon, Jana Vandrovcova, Özlem Yayıcı Köken, Sharika Raga, Kireshnee Naidu, Maryke Schoonen, Nimita Rani, Pedro Tomaselli, Dipti Baskar, Musambo Kapapa, Ipek Polat, Lindsay A Wilson, Kumarasamy Thangaraj, Uluç Yiş, Bevinahalli N Nandeesh, David Bearden, Michelle Kvalsund, Franclo Henning, Seena Vengalil, Atchayaram Nalini, Claudia F. R. Sobreira, Wilson Marques, Haluk Topoloğlu, Michael G Hanna, Sireesha Yareeda, Venugopalan Y Vishnu, Francois H van der Westhuizen, Izelle Smuts, Surita Meldau, Jo Wilmshurst, Büşranur Çavdarlı, Jeannine Heckmann, Patrick F Chinnery, Rita Horvath   +34 more
wiley   +1 more source

Tremor pathophysiology: lessons from neuroimaging.

Current Opinion in Neurology, 2020
PURPOSE OF REVIEW We discuss the latest neuroimaging studies investigating the pathophysiology of Parkinson's tremor, essential tremor, dystonic tremor and Holmes tremor.
Madelein van der Stouwe, F. Nieuwhof, R. Helmich   +2 more
semanticscholar   +1 more source

LINC00323 variant is associated with increased risk of essential tremor

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Essential tremor (ET) is a common adult movement disorder, with accumulating evidence suggesting that genetic factors primarily account for ET risk. However, replication studies on the genetic variants have yielded inconsistent results. In our case–control study, we show that the LINC00323 variant, identified in a European GWAS study, is ...
Brendan Tan, Ebonne Ng, Qiao Yang Sun, Aaron Mai, Ling‐Ling Chan, Thomas Welton, Kumar M. Prakash, Kay Yaw Tay, Wing Lok Au, Louis C.S. Tan, Eng‐King Tan, Bin Xiao   +11 more
wiley   +1 more source

A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS

BMC Neurology, 2020
Background Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset, X-linked genetic, neurodegenerative disorder caused by a “premutation (PM)” in the fragile X mental retardation 1 (FMR1) gene. Here we report a case of FXTAS from mainland of
Cuiping Zhao, Yiming Liu, Yihua Wang, Hongyan Li, Bin Zhang, Yaoxian Yue, Jianyuan Zhang   +6 more
doaj   +1 more source

Nonvolcanic tremor observed in the Mexican subduction zone [PDF]

, 2008
Nonvolcanic tremor (NVT) activity is revealed as episodes of higher spectral amplitude at 1–8 Hz in daily spectrograms from the continuous seismological records in Guerrero, Mexico.
Clayton, Robert W., Iglesias, Arturo, Kostoglodov, Vladimir, Mikumo, Takeshi, Payero, Juan S., Pérez-Campos, Xyoli, Shapiro, Nikolai   +6 more
core   +3 more sources

Deep-Brain Stimulation for Essential Tremor and Other Tremor Syndromes: A Narrative Review of Current Targets and Clinical Outcomes

Brain Science, 2020
Tremor is a prevalent symptom associated with multiple conditions, including essential tremor (ET), Parkinson’s disease (PD), multiple sclerosis (MS), stroke and trauma.
C. Iorio-Morin, A. Fomenko, Suneil K. Kalia   +2 more
semanticscholar   +1 more source

Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy [PDF]

, 2012
Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed to accommodate low-weight ...
Dearborn, Joshua T, Farber, Nuri B, Fowler, Stephen C, Reddy, Adarsh S, Sands, Mark S, Wozniak, David F   +5 more
core   +4 more sources

Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor

Tremor and Other Hyperkinetic Movements, 2020
Highlights This prospective study is one of the largest clinical trials in essential tremor to date. Study findings suggest that individualized non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective ...
S. Isaacson, E. Peckham, W. Tse, Olga Waln, Christopher Way, Melita Petrossian, N. Dahodwala, M. Soileau, M. Lew, Cameron Dietiker, Nijee S Luthra, P. Agarwal, R. Dhall, J. Morgan, N. Calakos, T. Zesiewicz, E. Shamim, R. Kumar, P. LeWitt, H. Shill, A. Simmons, F. Pagán, Pravin Khemani, Jessica Tate, B. Maddux, Lan Luo, W. Ondo, M. Hallett, A. Rajagopal, Paula Chidester, K. Rosenbluth, S. Delp, R. Pahwa   +32 more
semanticscholar   +1 more source

CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu, Wentao Chen, Yahong Wu, Zhen Guo, Jun Chen, Chen Tian, Pan Wang, Shaopeng Zeng, Bin Xu, Jing Duan, Shilong Han, Xiao Xiong, Jing Zhang   +12 more
wiley   +1 more source

Characteristics of Task-specific Tremor in String Instrument Players

Tremor and Other Hyperkinetic Movements, 2014
Background: In recent studies primary bowing tremor has been described; however, tremor frequency has never been quantitatively assessed. In addition to describing phenomenological aspects of tremor we thus aimed at assessing tremor frequency.
André Lee, Mareike Chadde, Eckart Altenmüller, Erwin Schoonderwaldt   +3 more
doaj   +1 more source