Results 101 to 110 of about 284,386 (244)
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng +7 more
wiley +1 more source
Endocarditis due to Bartonella quintana, the etiological agent of trench fever. [PDF]
CMAJ, 2020 Boodman C, Wuerz T, Lagacé-Wiens P.
europepmc +1 more source
Outbreaks of tularemia in Russia (1997–2023)
Эпидемиология и вакцинопрофилактикаRelevance. Currently, much attention is paid worldwide to diseases transmitted by vectors (bites of ticks, mosquitoes and horseflies). In our country, at least nine pathogens of zoonotic infections transmitted by this route are registered: tularemia ...
T. N. Demidova +5 more
doaj +1 more source
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
Palaeoseismological evidence of the 1570 Ferrara earthquake
, 2014 The May 20, 2012 Emilia earthquake (Mw = 6.1) produced secondary ground deformation effects, mainly associated with liquefaction phenomena, in several parts of the epicentral region, but particularly concentrated in the western sector of the Ferrara ...
San Carlo trench Working Group +1 more
core +1 more source
Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality
BMEMat, EarlyView.Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim +9 more
wiley +1 more source
Carrion ecology: concepts, interdisciplinary synthesis, and perspectives
Biological Reviews, EarlyView.ABSTRACT Carrion is a ubiquitous resource in both terrestrial and aquatic ecosystems, yet it has long been overlooked in ecological research. Over the past two decades, studies on carrion and the many organisms that exploit it have flourished, revealing not only wide‐ranging ecological functions but also significance far beyond ecology.
Marcos Moleón +38 more
wiley +1 more source
Scientific ReportsBartonella quintana, the causative agent of trench fever, is an intracellular bacterium that infects human erythrocytes and vascular endothelial cells. For many years, humans were considered the only natural hosts for B.
Shingo Sato +3 more
doaj +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT While industry platforms are widely recognized as enablers of circular innovation, we still know little about how they evolve to scale and sustain innovation as economic conditions tighten and circular economy funding schemes become more selective.
Eva Qi Wang +3 more
wiley +1 more source