Results 151 to 160 of about 3,342,431 (305)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Behaviour of Dickey-Fuller Unit Root Tests Under Trend Misspecification [PDF]
We analyse the case where a unit root test is based on a Dickey-Fuller regression whose only deterministic term is a fixed intercept. Suppose, however, as could well be the case, that the actual data generating process includes a broken linear trend.
Tae-Hwan Kim +2 more
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Monetary Policy, Trend Inflation and the Great Moderation: An Alternative Interpretation [PDF]
With positive trend inflation, the Taylor principle is not enough to guarantee a determinate equilibrium. We provide new theoretical results on restoring determinacy in New Keynesian models with positive trend inflation and combine these with new ...
Olivier Coibion, Yuriy Gorodnichenko
core
Six decades of trends in BMI, thinness, overweight, and obesity among 210,927 Swedish children in different socioeconomic contexts. [PDF]
BMC Public HealthBygdell M +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Trend-cycle-seasonal interactions: Identification and estimation
, 2018 Economists typically use seasonally adjusted data in which the assumption is imposed that seasonality is uncorrelated with trend and cycle. The importance of this assumption has been highlighted by the Great Recession. The paper examines an unobserved
Jacobs, JPAM (15626792) +3 more
core
Comments on Research trends of macrophage polarization: a bibliometric analysis
Chinese Medical Journal, 2019 Yuh-Shan Ho, Yuan-Yuan Ji
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Three Essays on Trend Analysis and Misspecification in Structural Econometric Models
, 2003 The purpose of this research has been to look into several econometric issues of concern to researchers doing applied work in macroeconomics. The first essay looks at Bureau of Economic Analysis data on inventories and sales of finished goods often used ...
Doorn, David John
core