Results 251 to 260 of about 7,486,166 (326)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Accuracy of Noninvasive Hemoglobin and Venous Blood Gas Hemoglobin Measurements in Comparison With the Laboratory Method in an Intensive Care Unit. [PDF]

Cureus
Elmaghrabi MM, Alatifi A, Alsoofi N, Ahmed N, Rauf S, Yassin MT, Sobh O.   +6 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Evaluating a multifaceted stewardship intervention on proton pump inhibitor utilization: an interrupted time-series analysis of prescribing patterns in a northwest Chinese hospital. [PDF]

Front Pharmacol
Wang X, McIver DJ, Min H, Guo J, Li H.
europepmc   +1 more source

Global Agricultural Adaptation Case Database and Trend Analysis Based on Large Language Models

Jingwen Zhong, Xueyan Zhang, Xin Ma
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Estimating Trends With Differential Item Functioning: A Comparison of Five IRT-Based Approaches. [PDF]

Educ Psychol Meas
Engels O, Lüdtke O, Robitzsch A.
europepmc   +1 more source

Comprehensive Review and Analysis of Wind Energy Forecasting Models Using Deep Learning: Current Trends, Gaps, and Future Directions

Edgar A. Manzano, Rubén Nogales, Alberto Ríos   +2 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections. [PDF]

JACC Basic Transl Sci
Zou Y, Wei S, Ren Q, Zhou T, Lu S, Li R, Ma Y, Yuan L, Wang J, She W, Guo X, Tao J, Bi S, Tian H, Sun C, Chen H, Xu J, Dong Y, Kang J, Lv H, Jiang Y, Zhang M.   +21 more
europepmc   +1 more source