Results 81 to 90 of about 3,342,431 (305)

The Impact of Wooden Design on User Satisfaction in Music Halls Based on a Serial Mediation Model: The Chain Mediation Mechanism of Perceived Restorativeness and Musical Resonance

Buildings
With the widespread use of sustainable building materials and the rise of emotional design, the use of wooden elements in public large-scale architecture has garnered significant attention.
Yuyan Chen, Siqin Wang, Haohao Yang, Ken Nah   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Multivariate trend comparisons between autocorrelated climate series with general trend regressors [PDF]

Inference regarding trends in climatic data series, including comparisons across different data sets as well as univariate trend significance tests, is complicated by the presence of serial correlation and step-changes in the mean.
Timothy Vogelsang, Ross McKitrick
core  

Targeting Terrestrial Vertebrates With eDNA: Trends, Perspectives, and Considerations for Sampling

Environmental DNA
Terrestrial vertebrates are experiencing worldwide population declines and species extinctions. To effectively conserve remaining populations and species, rapid, cost‐effective, and scalable methods are needed to complement longstanding monitoring ...
Joshua P. Newton, Morten E. Allentoft, Philip W. Bateman, Mieke van derHeyde, Paul Nevill   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Trend-resistant design of experiments under budget constraints. [PDF]

When experiments are to be performed in a time sequence, the observed responses are affected by a time trend. The construction of trend-resistant run orders is extensively described in the literature.
Tack, Lieven, Vandebroek, Martina
core  

Millennials’ Consumption Intention Toward Green Stadiums in the Context of Environmental Law: The Roles of Facility Visibility, Green Communication, and Interactive Experience

Buildings
Promoting the green development of large public buildings is a crucial pathway toward environmental sustainability. As a type of public building characterized by both high energy consumption and high public engagement, green stadiums provide an important
Bin Guo, Siqin Wang, Ken Nah
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Testing for a unit root in the presence of a possible break in trend [PDF]

In this paper we consider the issue of testing a time series for a unit root in the possible presence of a break in a linear deterministic trend at some unknown point in the series.
David I. Harvey, Stephen J. Leybourne, David Harris, A. M. Robert Taylor   +3 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source