Results 181 to 190 of about 6,114,826 (359)

Trends in early-onset cancer incidence rates in the Nordic countries (2003-2022): a population-based study. [PDF]

Lancet Reg Health Eur
Johansson AL, Kønig SM, Cardoso R, Møller H, Ursin G, Skog A, Persson Å, Birgisson H, Kristjánsdóttir L, Tanskanen T, Dahl-Olsen ED, Bray F, Friis S, Lambe M.   +13 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Community-Based Prevention: Findings From Nearly 3 Decades of the Drug-Free Communities Support Program. [PDF]

J Public Health Manag Pract
O'Donnel BK, Moss BG, Cooley KA, Morales V.   +3 more
europepmc   +1 more source

Trends in Nutrition [PDF]

BMJ, 1941
openaire   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Using MPC as master controller for integrated gasification combined cycle processes

, 2003
The aim of this work is the design of a master controller for IGCC (Integrated Gasification Combine Cycle) plant, based on an MPC (Model Predictive Control) approach, which is able to coordinate the main process variables interacting with the basic ...
F. Rusconi, ROVAGLIO, MAURIZIO, Bemporad, Alberto, Rovaglio, M., Rusconi, F., Morari, Manfred, A. Bemporad, M. Morari   +7 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Incidence rates of diagnosed anxiety and depressive disorders in Québec, Canada: changes in trends after the COVID-19 pandemic using interrupted time series methods. [PDF]

BMJ Open
Arpin E, Massamba V, Rochette L, Dialahy I, Quesnel-Vallée A, Nazif-Muñoz JI.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Illusory early-warning signals of Greenland Ice Sheet destabilization. [PDF]

Proc Natl Acad Sci U S A
Robel AA, Holly G, Ambelorun AA.
europepmc   +1 more source