Results 181 to 190 of about 10,671,013 (402)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison and trend of perioperative outcomes between robot-assisted radical prostatectomy and open radical prostatectomy: nationwide inpatient sample 2009-2014

, 2021
Yingyi Qin, Hedong Han, Yongping Xue, Cheng Wu, Wei, Xin, Yuzhou Liu, Yang Cao, Yiming Ruan, Jia He   +8 more
openalex   +1 more source

Trends in condensed matter physics: is research going faster and faster?

, 2012
In this paper we study research trends in condensed matter physics. Trends are analyzed by means of the the number of publications in the different sub-fields as function of the years.
Attaccalite, C., Barland, S.
core   +1 more source

Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.

Journal of the American Medical Association (JAMA), 2012
K. Flegal, M. Carroll, Brian K. Kit, Cynthia L Ogden   +3 more
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Trends in the timing of first marriage among men and women in the developing world [Arabic]

, 2005
Barbara Mensch, Susheela Singh, John B. Casterline   +2 more
openalex   +2 more sources

Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.

Journal of the American Medical Association (JAMA), 2012
Cynthia L Ogden, M. Carroll, Brian K. Kit, K. Flegal   +3 more
semanticscholar   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Mediation: International Experience and Global Trends

, 2018
Neil Andrews
openalex   +1 more source

3 Global productivity trends: Reviving growth through the digital economy? [PDF]

, 2023
Daniel Samaan, Miguel Sanchez Martinez
openalex   +1 more source