Results 151 to 160 of about 40,072 (246)

Putative mechanisms of ocular inflammation in syphilis. [PDF]

open access: yesJ Ophthalmic Inflamm Infect
Ashander LM   +5 more
europepmc   +1 more source

Shotgun Metagenomic Analysis Reveals Taxonomic and Functional Transitions in the Salivary Microbiome During Periodontal Disease Progression

open access: yesJournal of Clinical Periodontology, Volume 53, Issue 11, Page 1650-1662, November 2026.
ABSTRACT Aim To characterise multi‐kingdom salivary microbiome profiles across clinically defined periodontal states and identify stage‐specific taxonomic and functional alterations using shotgun metagenomic sequencing. Materials and Methods In this cross‐sectional study, 204 adults (mean age 40.3 ± 7.6 years) from the SECRETO study (NCT01934725 ...
Muhammed Manzoor   +6 more
wiley   +1 more source

German guideline on neurosyphilis. [PDF]

open access: yesNeurol Res Pract
Klein M   +11 more
europepmc   +1 more source

Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria   +5 more
wiley   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

open access: yesBiotechnology and Applied Biochemistry, Volume 73, Issue 5, Page 2457-2481, October 2026.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva   +8 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Drug‐Drug Interactions Between Cofrogliptin and Metformin in Healthy Subjects: A Single‐Center, Single‐Arm, Phase I Study in China

open access: yesClinical Pharmacology in Drug Development, Volume 15, Issue 10, October 2026.
Abstract This single‐center, single‐arm, Phase I study evaluated drug–drug interactions (DDIs) between cofrogliptin and metformin in healthy Chinese subjects. Twenty‐two subjects sequentially received metformin monotherapy (Days 1–4), cofrogliptin monotherapy (Days 6–34), and combination therapy (Days 38–47).
Cheng Cui   +8 more
wiley   +1 more source

Diagnostic Accuracy of Salivary Thiols Point‐of‐Care Test for Detecting Subgingival Dysbiosis in Adults: A Cross‐Sectional Study

open access: yesClinical and Experimental Dental Research, Volume 12, Issue 5, October 2026.
ABSTRACT Objectives Many bacteria implicated in the pathogenesis of periodontitis produce thiol compounds containing sulfhydryl (‐SH) groups. This cross‐sectional study used a prototype chromogenic test strip to investigate the relationship between whole saliva ‐SH levels and subgingival bacterial species in subjects with and without periodontal ...
Ahmed Khocht   +3 more
wiley   +1 more source

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