Results 11 to 20 of about 254 (146)
The role of TREX in gene expression and disease [PDF]
Biochemical Journal, 2016 TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway. In addition, this complex prevents DNA damage and regulates the
Heath, C.G., Viphakone, N., Wilson, S.A.
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Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex
Nature Communications, 2023 Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins localized at the nucleoplasmic side of the NPC ...
Prasanna Bhat +18 more
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Ten-fold Robust Expansion Microscopy
Bio-Protocol, 2023 Expansion microscopy (ExM) is a powerful technique to overcome the diffraction limit of light microscopy that can be applied in both tissues and cells.
Hugo Damstra +5 more
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Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA [PDF]
Nucleic Acids Research, 2012 The mRNA export complex TREX (TREX) is known to contain Aly, UAP56, Tex1 and the THO complex, among which UAP56 is required for TREX assembly. Here, we systematically investigated the role of each human TREX component in TREX assembly and its association with the mRNA. We found that Tex1 is essentially a subunit of the THO complex.
Chi, Binkai +7 more
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Structure of the human core transcription-export complex reveals a hub for multivalent interactions
eLife, 2020 The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export ...
Thomas Pühringer +6 more
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PLoS Pathogens, 2022 Influenza A viruses effectively hijack the intracellular "resources" to complete transcription and replication, which involve extensive interactions between the viral and host proteins.
Lingcai Zhao +5 more
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About Fast and TReX Accelerations
Electronic Notes in Theoretical Computer Science, 2005 AbstractFast and TReX tools are designed to analyse systems with infinite state spaces. They both implement algorithms computing the set of reachable states of such systems. Since the state space may be infinite, acceleration techniques are used.
Darlot, Christophe +2 more
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PCID2 Subunit of the Drosophila TREX-2 Complex Has Two RNA-Binding Regions
Current Issues in Molecular Biology, 2023 Drosophila PCID2 is a subunit of the TREX-2 mRNA nuclear export complex. Although the complex has long been studied in eukaryotes, it is still unclear how TREX-2 interacts with mRNA in multicellular organisms.
Yulia A. Vdovina +3 more
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HYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis. [PDF]
PLoS Genetics, 2015 Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1) represses ethylene hormone responses by promoting ethylene receptor ETHYLENE RESPONSE1 (ETR1) signaling, which negatively regulates ethylene responses.
Congyao Xu, Xin Zhou, Chi-Kuang Wen
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Topology Adaptive Graph Estimation in High Dimensions
Mathematics, 2022 We introduce Graphical TREX (GTREX), a novel method for graph estimation in high-dimensional Gaussian graphical models. By conducting neighborhood selection with TREX, GTREX avoids tuning parameters and is adaptive to the graph topology.
Johannes Lederer, Christian L. Müller
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