Results 31 to 40 of about 288,499 (216)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

FAMILY KNOWLEDGE AND PREPAREDNESS IN FACING FLOOD DISASTERS IN BENGKULU CITY

Nurse and Health
Background: Floods are natural events that can occur at any time and often result in loss of life and property. Losses due to flooding can be in the form of damage to buildings, loss of valuables, so that the losses that result cannot be prevented, but ...
Loren Juksen, Yulita Elvira, Desi Fitriani, Ida Rahmawati   +3 more
doaj   +1 more source

Multiple interaction nodes define the postreplication repair response to UV‐induced DNA damage that is defective in melanomas and correlated with UV signature mutation load

Molecular Oncology, 2020
Ultraviolet radiation‐induced DNA mutations are a primary environmental driver of melanoma. The reason for this very high level of unrepaired DNA lesions leading to these mutations is still poorly understood.
Sandra Pavey, Alex Pinder, Winnie Fernando, Nicholas D’Arcy, Nicholas Matigian, Dubravka Skalamera, Kim‐Anh Lê Cao, Dorothy Loo‐Oey, Michelle M. Hill, Mitchell Stark, Michael Kimlin, Andrew Burgess, Nicole Cloonan, Richard A. Sturm, Brian Gabrielli   +14 more
doaj   +1 more source

Antibiogram of Salmonella spp Isolates from Raw Chicken Meat of Kathmandu Valley

Nepal Journal of Biotechnology, 2023
Salmonella is one of the pathogenic microbe responsible in food borne diseases. In developing countries like Nepal,  Salmonellosis is one of the leading food-borne disease.
Abhimat Subedi, Asmita Aryal, Dwarika Ojha, Prabesh Dulal, Sanjeev Jha, Bidya Ghale, Shova Shrestha   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Characterization of Polypropylene Green Composites Reinforced by Cellulose Fibers Extracted from Rice Straw

International Journal of Polymer Science, 2018
Polypropylene (PP) based green composites containing 10, 20, 30, 40 and 50 wt% of cellulose fibers (CFs) which were extracted from rice straw were successfully prepared by melt blend method. The CFs washed with H2O2 after alkaline extraction showed lower
Ngo Dinh Vu, Hang Thi Tran, Toan Duy Nguyen   +2 more
doaj   +1 more source

Sustainable Governance to Improve the Performance of SOEs Bank Listed on Indonesian Stock Exchange that are Classified as LQ45

Majalah Ilmiah Bijak, 2020
Corporate governance is useful for improving company performance. Company performance can be in the form of financial performance or non-financial performance. In this digital era, the role of governance is very important.
Mochamad Muslih, Dahlia Banjarnahor
doaj   +1 more source

Clinical outcome and pathologic correlation of stereotactic body radiation therapy as a bridge to transplantation for advanced hepatocellular carcinoma: a case series

Radiation Oncology, 2021
Background Stereotactic body radiotherapy (SBRT) is an emerging modality for hepatocellular carcinoma (HCC). However, there is scant information about its safety and effectiveness in the neoadjuvant setting prior to liver transplantation (LT). We present
Ying-Fu Wang, Yang-Hong Dai, Chun-Shu Lin, Hao-Chih Chang, Po-Chien Shen, Jen-Fu Yang, Chih-Weim Hsiang, Cheng-Hsiang Lo, Wen-Yen Huang   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source