Results 121 to 130 of about 2,302,312 (219)

An independent appraisal and re-analysis of hydroxychloroquine treatment trial for COVID-19

Swiss Medical Weekly, 2020
Katheron Intson, Sachin A. Kumar, Amy Botta, Rachael Neckels, Connie Leung, Ali Jawaid   +5 more
doaj   +1 more source

Coenrollment of critically ill patients in PROSPECT: A protocol and statistical analysis plan. [PDF]

PLoS One
Thabane A, Heels-Ansdell D, Zytaruk N, Cook D, PROSPECT Investigators and the Canadian Critical Care Trials Group.   +4 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Open-label randomised controlled trial of aripiprazole/sertraline combination in comparison with quetiapine for the clinical and cost-effectiveness of treatment of bipolar depression (the ASCEnD study): study protocol. [PDF]

BMJ Open
Azim L, Al-Ashmori S, Butcher C, Cipriani A, Chew-Graham CA, Clare E, Clark E, Cole M, Carella S, Dixon L, Evans J, Gergel T, Gibson J, Hancock HC, Hoppe I, Kessler D, Kabir T, Lewis G, Mathias A, Morris R, Nixon N, Simon J, Teare MD, Lived Experience Advisory Panel, Wahba M, Wall L, Walmsley Z, Wienand D, Wolstenhulme F, Ahuja N, Watson S.   +30 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Listening to Australians with ovarian cancer: a cross-sectional survey investigating clinical trials awareness, information access and participation. [PDF]

Support Care Cancer
Williams N, Lee YC, Russell H, Andrews J, Chen WS, Bradhurst B.   +5 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid. [PDF]

BMJ Open
Dunn S, Evans L, Kennedy C, Wafer R, Moody S, Wolstenhulme F, Burton E, Konkoth AB, Fisher H, Chadwick T, Banham A, Hale F, Christie M, Barclay ST, Dyson J, Smith R, Aithal G, Culver E, Aspinall R, Thorburn D, Heneghan M, Hancock HC, Trivedi P, Mells G, Wason J, Jones DEJ.   +25 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Assessment of Participant Satisfaction and Overall Experience: A Cross-Sectional Survey to Inform Trial Conduct. [PDF]

Patient Prefer Adherence
Al-Maqbali JS, Al Alawi AM, Al-Zakwani I, Al Za'abi M.   +3 more
europepmc   +1 more source