Results 161 to 170 of about 9,492,801 (363)

Randomized controlled trial

, 2016
Jason McMullan, Christopher Droege, Col. Richard Strilka, Kimberly Hart, C. Lindsell   +4 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Three approaches to determining clinically meaningful benefit on the Cohen‐Mansfield Agitation Inventory in dementia clinical trials for agitation

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION There is a need to understand the clinical meaningfulness of symptom score changes in treatment trials of dementia‐related agitation. We estimated minimal clinically important differences (MCIDs) for commonly employed agitation scales and ...
Kathy Y. Liu, Chineze Ivenso, Rebecca Howard, Penny Rapaport, Suzanne Reeves, Sube Banerjee, Lon S. Schneider, Maria I. Lapid, Agitation MCID Study Group, Robert Howard   +9 more
doaj   +1 more source

Oat Variety Trial Report [PDF]

, 2010
Oats (Avena sativa L.) have a long history of being grown in the Northeast. Although most of the oats are planted for a cover crop or hay, growing oats for grain is another potential revenue source for farmers.
Cummings, Erica, Darby, Heather, Gervais, Amanda, Halteman, Philip, Madden, Rosalie, Monahan, Susan   +5 more
core   +1 more source

Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial

Stroke, 1993
Timothy Carter, J. W. Tulloch, Mario Mendez, R. Tarrel, M. Nance, Scott R. Budlie, R. Shapiro, K. Ruggles, P. Gottschalk, Rodney W. Sorenson, D. Jacobson, John G. Schmidt   +11 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Winter Canola Variety Trial [PDF]

, 2012
In 2012, the University of Vermont Extension Northwest Crops and Soils Program initiated a winter canola variety trial in Alburgh, VT as part of the 2011-2012 National Winter Canola Variety Trial.
Blair, Katie, Cummings, Erica, Darby, Heather, Harwood, Hannah, Madden, Rosalie, Monahan, Susan   +5 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Chest Pain Choice Decision Aid: A Randomized Trial

Circulation. Cardiovascular Quality and Outcomes, 2012
E. Hess, Meghan A. Knoedler, N. Shah, J. Kline, M. Breslin, M. Branda, Laurie J. Pencille, B. Asplin, D. Nestler, A. Sadosty, I. Stiell, H. Ting, V. Montori   +12 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source