Results 91 to 100 of about 13,925,367 (271)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A Generalized Series Solution for the Boussinesq Equation With Constant Boundary Conditions

Water Resources Research, 2019
In this work we consider the Boussinesq equation applied to a one‐dimensional homogeneous aquifer with constant boundary conditions. Such a problem is generally solved (both analytically and numerically) by transforming it from a boundary value problem ...
Tomas Chor, Ailín Ruiz de Zárate, Nelson L. Dias   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Survival analysis following dynamic randomization

Contemporary Clinical Trials Communications, 2016
In this paper, we propose a method to analyze survival data from a clinical trial that utilizes a dynamic randomization for subject enrollment. The method directly accounts for dynamic subject randomization process using a marked point process (MPP). Its
Xiaolong Luo, Mingyu Li, Gongjun Xu, Dongsheng Tu   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Trefftz spectral method for initial-boundary problems

Computer Assisted Methods in Engineering and Science, 2023
We describe a new Quasi Trefftz-type Spectral Method (QTSM) for solving boundary value and initial value problems. QTSM combines the properties of the Trefftz method with the spectral approach.
Sergei Lifits, Sergei Reutskiy, Brunello Tirozzi   +2 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Petrov-Galerkin Method and Chebyshev Multiwavelet Basis for Solving Integro-Differential Equations

International Journal of Industrial Engineering and Production Research, 2007
: There are some methods for solving integro-differential equations. In this work, we solve the general-order Feredholm integro-differential equations. The Petrov-Galerkin method by considering Chebyshev multiwavelet basis is used.
k. Maleknejad, M. Rabbani
doaj  

Analytical evaluations using neural network-based method for wave solutions of combined Kairat-II-X differential equation in fluid mechanics

Scientific Reports
In this paper, a symbolic computation method based on a neural network architecture, the improved neural network-based method, for obtaining novel exact solutions to combined Kairat-II-X differential equation is proposed.
Ping Zhou, Jalil Manafian, Mehrdad Lakestani, Onur Alp Ilhan, Nayier Jangi Bahador, A. A. Fattah, K. H. Mahmoud, Rzayeva Nuray, Nigar Nagiyeva   +8 more
doaj   +1 more source