Results 231 to 240 of about 506,753 (297)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Efficacy of Tegafur-Uracil Maintenance Therapy in Non-Metastatic Head and Neck Squamous Cell Carcinoma: A Meta-Analysis With Trial Sequential Analysis. [PDF]

World J Oncol
Lee HL, Lee CH, Dai MS, Chu YH, Lee JC, Chen PH, Chen JH.   +6 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Small versus large bore chest tube in traumatic hemothorax, hemopneumothorax, and pneumothorax: a meta-analysis of randomized controlled trials with trial sequential analysis. [PDF]

World J Emerg Surg
Granieri S, Cioffi SPB, Asaro A, Altomare M, Spota A, Virdis F, Bini R, Gupta S, Davis K, Cimbanassi S.   +9 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Aspirin for the extended prevention of venous thromboembolism: a meta-analysis and trial sequential analysis. [PDF]

Sci Rep
Carron M, Tamburini E, Pettenuzzo T, Zarantonello F, Campello E, Navalesi P, Simioni P.   +6 more
europepmc   +1 more source

Endovascular thrombectomy for large-core stroke: a meta-analysis with trial sequential analysis. [PDF]

Arq Neuropsiquiatr
Santos MARD, Moro P, Souza ALB, Nirta L, Mendes TP, Xavier LL, Ding MC.   +6 more
europepmc   +1 more source

Prevalence and risk of thyroid disease among adult primary aldosteronism patients: a systematic review, meta-analysis, and trial sequential analysis. [PDF]

Front Endocrinol (Lausanne)
Hu W, Wu Y, Li P.
europepmc   +1 more source

Effect of Neurokinin-1 Receptor Antagonists on Experimental Postoperative Adhesion: A Systematic Review and Meta-Analysis with Trial Sequential Analysis of Preclinical Studies. [PDF]

Medicina (Kaunas)
Hwang HJ, Choi GJ, Choi YS, Kim BG, Kang H.   +4 more
europepmc   +1 more source