Results 71 to 80 of about 116,263,120 (276)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Verdict Reasonable at Casey Anthony Trial

open access: yes, 2011
The Casey Anthony trial verdict was reasonable if the jury did not believe she was guilty beyond a reasonable doubt. To prevent the wrongful conviction of innocents, a preponderance of the evidence standard is not used in criminal ...
Loewy, Arnold H.
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The clinical utility of the AUSDRISK tool in assessing change in type 2 diabetes risk in overweight/obese volunteers undertaking a healthy lifestyle intervention

open access: yesPreventive Medicine Reports, 2019
The objective of this study was to assess the clinical utility of the AUSDRISK tool for determining risk of Type 2 diabetes mellitus (T2DM). In this secondary analysis from the HealthTrack study, the AUSDRISK tool was applied to data from overweight ...
Allison Martin   +2 more
doaj   +1 more source

The use of robots/artificial intelligence by the courts and the trial within a reasonable time

open access: yes, 2021
Artificial Intelligence has reached the legal environment, bringing ease to the Courts and expanding possibilities for conflict resolution benefiting countless people. Like this, the advance was directed at the judges and the judiciary. Faced with such a transformation social and professional, this work presents the commitment of technological systems ...
Terron, Leticia Sangaleto   +1 more
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Right To Trial Within A Reasonable Time

open access: yes, 2011
Adil yargılanma ilkesi sadece anayasa hukuku ve muhakeme hukukunun önemli bir ilkesi olarak değil aynı zamanda hukuk devleti ilkesinin bir getirisi olarak Avrupa ortak anayasal düzeninin temel bir değeri olarak kabul edilmiştir.
Senturk, C., Bayzit, T.
core  

Right to a trial within a reasonable time in criminal proceedings

open access: yes, 2022
Pravo na suđenje u razumnom roku ima ogromnu važnost u ostvarenju pravilnog i zakonitog sudskog postupka. To vrijedi i za kaznene postupke. U radu je objašnjen pojam prava na suđenje u razumnom roku, a u uvodnom je dijelu poseban naglasak stavljen na ...
Jozak, Stanko
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

sj-pdf-4-hpq-10.1177_13591053211037736 – Supplemental material for A qualitative investigation of reasoning behind decisions to decline participation in a research intervention: A study-within-a-trial

open access: yes, 2021
Supplemental material, sj-pdf-4-hpq-10.1177_13591053211037736 for A qualitative investigation of reasoning behind decisions to decline participation in a research intervention: A study-within-a-trial by Christopher P Dwyer, Anusha Moses, Fionnuala M ...
Fionnuala M Rogers (11260364)   +5 more
core   +1 more source

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