Results 1 to 10 of about 4,145 (180)

Neurotoxic Effects of Acute Tributyltin Exposure in Adult Zebrafish: Behavioral Impairments and Mechanistic Insights [PDF]

Metabolites
Background/Objectives: Tributyltin (TBT) remains a persistent aquatic contaminant with documented neurotoxic effects, yet the underlying mechanisms of its neurotoxicity remain poorly understood.
Qi Zheng, Nan Hong, Lin Liu, Cong Wang, Ruixi Gan, Di Xu, Junsong Wang   +6 more
doaj   +2 more sources

Tributyltin Alters Seric Bile Acid Pool Composition in Male Rats [PDF]

Toxics
Tributyltin (TBT), a recognized endocrine disruptor, is associated with metabolic diseases, including obesity, type 2 diabetes, non-alcoholic steatohepatitis, and osteoporosis.
Wenhuan Yao, Jinjiao Luan, Hui Li, Dong Cheng, Shibo Lv, Jiliang Si   +5 more
doaj   +2 more sources

Tributyltin Alters Hepatic Immune Microenvironment to ProMote Liver Fibrosis Progression in Rats [PDF]

Toxics
Tributyltin (TBT) is well known for inducing imposex in mollusks. Studies have shown its hepatotoxicity and immunotoxicity in laboratory animals, with macrophages playing a crucial role in maintaining hepatic homeostasis and influencing disease ...
Nuo Zhou, Xiaoyu Si, Wenhuan Yao, Jiliang Si, Dong Cheng, Hui Li   +5 more
doaj   +2 more sources

Disruption of estrogen signaling by developmental exposure to BPA and TBT causes long term functional deficits in zebrafish retina [PDF]

Frontiers in Pharmacology
Bisphenol A (BPA) and tributyltin (TBT) are two endocrine disrupting compounds (EDC) that have opposite effects on estrogen signaling. BPA is an estrogen agonist that binds to all estrogen receptor types.
J. S. Jensen, J. S. Jensen, L. Ouellette, L. Ouellette, R. Harris, P. Owrang, V. P. Connaughton, V. P. Connaughton   +7 more
doaj   +2 more sources

Tributyltin and Zebrafish: Swimming in Dangerous Water [PDF]

Frontiers in Endocrinology, 2018
Zebrafish has been established as a reliable biological model with important insertion in academy (morphologic, biochemical, and pathophysiological studies) and pharmaceutical industry (toxicology and drug development) due to its molecular complexity and
Clemilson Berto-Júnior, Clemilson Berto-Júnior, Denise Pires de Carvalho, Denise Pires de Carvalho, Denise Pires de Carvalho, Paula Soares, Paula Soares, Paula Soares, Paula Soares, Leandro Miranda-Alves, Leandro Miranda-Alves, Leandro Miranda-Alves   +11 more
doaj   +4 more sources

Additives Promote Divergent Reactivity in Photolytic Deoxygenation and Lactonization Reactions of Cobalt Alkoxycarbonyls. [PDF]

European J Org Chem
We report a carbonylation‐homolysis process to access acyl radicals that can undergo decarboxylation or cyclization onto tethered alkenes. In both cases, ligands and additives are shown to influence the outcome to give saturated or unsaturated products, in some cases with isomerization of the initial products.
Hackbarth JN, Chambers DR, Ludwig CT, Brown TK, Martin DBC.   +4 more
europepmc   +2 more sources

Identification of pharmaceuticals and environmental contaminants as obesogens inducing a locomotion-independent thrifty phenotype [PDF]

Communications Biology
Obesity is a global pandemic that affects people of all ages. While behavioral, nutritional, and socioeconomic factors all contribute to weight gain, other factors in our immediate environment play an insidious role in the prevalence of obesity. Exposure
Sara Al Kassir, Théo Mercé, Laure M. Bourcier, Sandra Pedemay, Magalie Soares, Anja Knoll-Gellida, Patrick J. Babin   +6 more
doaj   +2 more sources

Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat

BMC Musculoskeletal Disorders, 2021
Background Tributyltin, a well-known endocrine disruptor, is widely used in agriculture and industry. Previous studies have shown that tributyltin could cause deleterious effects on bone health by impairing the adipo-osteogenic balance in bone marrow ...
Mingjun Li, Dong Cheng, Hui Li, Wenhuan Yao, Dongmei Guo, Shu’e Wang, Jiliang Si   +6 more
doaj   +1 more source

Tributyltin Exposure Is Associated With Recognition Memory Impairments, Alterations in Estrogen Receptor α Protein Levels, and Oxidative Stress in the Brain of Female Mice

Frontiers in Toxicology, 2021
Tributyltin (TBT) is a persistent organometallic pollutant widely used in several agricultural and industrial processes. TBT exposure is associated with various metabolic, reproductive, immune, and cardiovascular abnormalities.
Igor Ferraz da Silva, Eduardo Merlo, Charles S. Costa, Jones B. Graceli, Lívia C. M. Rodrigues   +4 more
doaj   +1 more source

Oral Exposure to Tributyltin Induced Behavioral Abnormality and Oxidative Stress in the Eyes and Brains of Juvenile Japanese Medaka (Oryzias latipes)

Antioxidants, 2021
The widely used compound tributyltin (TBT), which can be continuously detected in aquatic species and seafood, may induce diverse adverse effects on aquatic organisms.
Yanhong Shi, Chen Chen, Ming Li, Lei Liu, Kejun Dong, Kun Chen, Xuchun Qiu   +6 more
doaj   +1 more source