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Trialkyltin Compounds Bind Retinoid X Receptor to Alter Human Placental Endocrine Functions [PDF]

open access: bronzeMolecular Endocrinology, 2005
AbstractRetinoid X receptor (RXR) is a nuclear receptor that plays important and multiple roles in mammalian development and homeostasis. We previously reported that, in human choriocarcinoma cells, tributyltin chloride and triphenyltin hydroxide, which are typical environmental contaminants and cause masculinization in female mollusks, are potent ...
Tsuyoshi Nakanishi
exaly   +4 more sources

The action of trialkyltin compounds on mitochondrial respiration. The effect of pH. [PDF]

open access: bronzeBiochem J, 1974
1. Inhibition of 2,4-dinitrophenol-stimulated respiration by trialkyltins is dependent on the presence of Cl− in the assay medium and is only apparent at acid pH values. It appears to be a result of the Cl−–OH− exchange mediated by trialkyltins. 2. In a KCl medium at alkaline pH values, the maximum rate of respiration produced by uncouplers is further ...
Dawson AP, Selwyn MJ.
europepmc   +6 more sources

The decrease of mitochondrial substrate uptake caused by trialkyltin and trialkyl-lead compounds in chloride media and its relevance to inhibition of oxidative phosphorylation [PDF]

open access: bronzeBiochemical Journal, 1975
1. In a 100 mM-KCl medium (pH 6.8) containing ATP, triethyltin (1 muM) causes a decrease in the uptake of pyruvate, malate, citrate or β-hydroxybutyrate by rat liver mitochondria, but no decrease is observed in a 100 mM-KNO3 medium. This response is not modified by the presence of rotenone in the incubation medium. 2.
David N. Skilleter
core   +6 more sources

Trialkyltin Compounds Enhance Human CG Secretion and Aromatase Activity in Human Placental Choriocarcinoma Cells [PDF]

open access: bronzeThe Journal of Clinical Endocrinology & Metabolism, 2002
Human choriocarcinoma cell lines have been used as placental models for the study of endocrine function, including aromatase (CYP19) activity and the secretion of human CG (hCG). In the present study, we investigated the effects of trialkyltin compounds, which are suspected endocrine disrupters, on aromatase activity and hCG secretion in human ...
Takashi Nakanishi
  +6 more sources

Comparative Study of Five Trialkyltin Compounds: Their Metabolites in Rat Organs 24 Hours after Single Oral Treatment

open access: diamondNippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 2007
The objective of this study is to provide basic information on the metabolic fate of five trialkyltins, namely, trimethyltin, triethyltin, tripropyltin, tributyltin, and trioctyltin, in rats.The levels of trialkyltin and its metabolites in the liver, kidneys, brain, and blood of rats and mice were determined 24h after single oral treatment with ...
Keita Watanabe   +2 more
openalex   +4 more sources

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