Results 11 to 20 of about 359 (103)

Metal‐Catalyzed Carbonylation Reactions with CO2: An Update

ChemCatChem, Volume 15, Issue 20, October 20, 2023., 2023
Catalytic carbonylation with CO2: The latest updates on C1‐carbonylative homologation of carbon scaffolds by means of metal catalyzed fixation of CO2 are collected in the present Review article. Innovative catalytic systems, enabling technologies and mechanistic investigations are contributing to the current developments of this fascinating research ...
Riccardo Giovanelli, Giulio Bertuzzi, Marco Bandini   +2 more
wiley   +1 more source

Strukturchemische Aspekte der Organozinnchemie

CHIMIA, 1962
In a short survey the fundamental difference between organometallic and organometalloid chemistry is related to the reverse polarity of carbon-metal bonds in comparison with bonds between carbon and other elements.
G. J. M. van der Kerk, J. G. A. Luijten, M. J. Janssen   +2 more
doaj   +1 more source

Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties

Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022
Lead optimization represents the tedious process of fine‐tuning lead compounds from biologically active hits to suitable drug candidates for clinical trials. By chemically modifying a hit structure, an improved compound can be obtained in terms of activity, selectivity, and pharmacokinetic ADME (absorption, distribution, metabolism, and excretion ...
Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe, Andrea Trabocchi   +5 more
wiley   +1 more source

Size‐Induced Inversion of Selectivity in the Acylation of 1,2‐Diols

Chemistry – A European Journal, Volume 27, Issue 72, Page 18084-18092, December 23, 2021., 2021
The Lewis‐base catalyzed acylation of aromatic 1,2‐ethylenediols with anhydrides depends strongly on the size of the reagents and the π‐system of the diol. Steric effects have a larger impact on reactions of primary hydroxyl groups in the 1,2‐diol as well as the monoester than those of secondary hydroxyl groups. For sterically demanding anhydrides this
Stefanie Mayr, Hendrik Zipse
wiley   +1 more source

The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling Arylations

Angewandte Chemie, Volume 133, Issue 20, Page 11168-11191, May 10, 2021., 2021
This Review focuses on methods developed as solutions for the challenging coupling of 2‐pyridyl nucleophiles with (hetero)aryl electrophiles. The topic encompasses traditional cross‐coupling processes, modifications to the Suzuki–Miyaura coupling, as well as alternative nucleophilic reagents and recent developments in C−H activation.
Xinlan A. F. Cook, Antoine de Gombert, Janette McKnight, Loïc R. E. Pantaine, Michael C. Willis   +4 more
wiley   +1 more source

Trialkyltin Compounds Enhance Human CG Secretion and Aromatase Activity in Human Placental Choriocarcinoma Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
Human choriocarcinoma cell lines have been used as placental models for the study of endocrine function, including aromatase (CYP19) activity and the secretion of human CG (hCG). In the present study, we investigated the effects of trialkyltin compounds, which are suspected endocrine disrupters, on aromatase activity and hCG secretion in human ...
Tsuyoshi, Nakanishi, Junya, Kohroki, Shizuko, Suzuki, Junichi, Ishizaki, Youhei, Hiromori, Shinri, Takasuga, Norio, Itoh, Yoshiteru, Watanabe, Naoki, Utoguchi, Keiichi, Tanaka   +9 more
openaire   +3 more sources

Reactivity and Steric Parameters from 2D to 3D Bulky Pyridines: Increasing Steric Demand at Nitrogen with Chiral Azatriptycenes

Angewandte Chemie, Volume 136, Issue 32, August 5, 2024.
Highly sterically hindered chiral pyridines were synthesized and resolved by HPLC. Their Brønsted/Lewis basicity were evaluated, and their reactivity was studied through their combination with Pd and B(C6F5)3 to generate new types of ligands/frustrated Lewis pairs. The study involved the first parameterization of the steric hindrance for a large set of
Ali Ben Saida, Damien Mahaut, Nikolay Tumanov, Johan Wouters, Benoît Champagne, Nicolas Vanthuyne, Raphaël Robiette, Guillaume Berionni   +7 more
wiley   +2 more sources

50 Years of Giese Reaction – a Personal View

Angewandte Chemie International Edition, Volume 65, Issue 7, 9 February 2026.
The Giese‐Reaction celebrates its 50. Birthday, it is a cyclic radical chain reaction centered around C,C‐bond formation in a three component synthesis. This minireview speaks about the birth of the name‐reaction, explains how the complete understanding of its reaction mechanism stimulates new methods in organic synthesis, and why it can proceed in ...
Martin Spichty, Hendrik Zipse, Salem Majouri, Katharina M. Fromm, Bernd Giese   +4 more
wiley   +1 more source

Unified Approach to Deamination and Deoxygenation Through Isonitrile Hydrodecyanation: A Combined Experimental and Computational Investigation

Angewandte Chemie, Volume 136, Issue 25, June 17, 2024.
We report a general hydrodefunctionalization protocol using isonitrile intermediates. Employing photoredox catalysis, a nucleophilic boryl radical mediates the scission of a relatively inert C−NC bond, accomplishing deletion of the isonitrile group. This strategy applies to the hydrodefunctionalization of both amine and alcohol‐containing compounds and
Ziqi Jiao, Kyle T. Jaunich, Thomas Tao, Olivia Gottschall, Maxwell M. Hughes, Aneta Turlik, Alexander W. Schuppe   +6 more
wiley   +2 more sources

Recent Developments in Radical Mediated Synthesis of Organostannanes.

Advanced Synthesis &Catalysis, Volume 367, Issue 12, June 26, 2025.
Abstract The present review aims to provide an overview of the recent developments in the preparation of aryl‐ or alkenyl stannanes via carbon‐ and tin‐centered radicals enabling chemists to synthesize organostannyl derivatives with high efficiency and under mild conditions.
Qianhang Ren, Adrian Luguera Ruiz, Maurizio Fagnoni, Stefano Protti, Di Qiu   +4 more
wiley   +1 more source