Results 91 to 100 of about 54,264 (302)

Trichomonas vaginalis Induces NLRP3 Inflammasome Activation and Pyroptotic Cell Death in Human Macrophages

Journal of Innate Immunity, 2018
Trichomonas vaginalis is a sexually transmitted, eukaryotic parasite that causes trichomoniasis, the most common nonviral, sexually transmitted disease in the USA and worldwide.
A. Riestra, J. A. Valderrama, K. Patras, Sharon D Booth, Xing Yen Quek, Chih-Ming Tsai, V. Nizet, V. Nizet   +7 more
semanticscholar   +1 more source

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Schistosomiasis, a neglected tropical disease infecting over 200 million people globally, has limited therapeutic options. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania, and we have previously demonstrated antischistosomal activity with inhibitors targeting ...
Elany B. Silva, Zhenze Jiang, Chenxi Liu, Pavla Fajtová, Thaiz R. Teixeira, Giovana de Castro Fiorini Maia, Lawrence J. Liu, Nelly El‐Sakkary, Danielle E. Skinner, Ali Syed, Steven C Wang, Conor R. Caffrey, Anthony J. O'Donoghue   +12 more
wiley   +1 more source

The parasite Trichomonas vaginalis expresses thousands of pseudogenes and long non-coding RNAs independently from functional neighbouring genes [PDF]

, 2014
BACKGROUND: The human pathogen Trichomonas vaginalis is a parabasalian flagellate that is estimated to infect 3% of the world’s population annually.
Christian Woehle, Claudia Radine, Dan Graur, Gary Kusdian, Giddy Landan, Sven B Gould   +5 more
core   +1 more source

Why Does Trichomonas vaginalis Continue to be a "Neglected" Sexually Transmitted Infection?

Clinical Infectious Diseases, 2018
Trichomonas vaginalis is the most common, curable nonviral sexually transmitted infection (STI) [1]. It is associated with premature rupture of membranes, preterm birth, low-birthweight infants, infertility, and increased risk of human immunodeficiency ...
C. Muzny
semanticscholar   +1 more source

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

Advanced Science, Volume 12, Issue 18, May 15, 2025.
An unprecedented high‐resolution spatial atlas of the E. multilocularis infection foci is obtained, revealing the dynamic functions of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The transition of parasite control strategy from “active killing” to “negative segregation” by the host may provide instructive insights into ...
Zhihua Ou, Li Li, Peidi Ren, Ting‐Ting Zhou, Fan He, Jialing Chen, Huimin Cai, Xiumin Han, Yao‐Dong Wu, Jiandong Li, Xiu‐Rong Li, Qiming Tan, Wenhui Li, Qi Chen, Nian‐Zhang Zhang, Xiuju He, Wei‐Gang Chen, Yanping Zhao, Jiwen Sun, Qian Zhang, Yan‐Tao Wu, Yingan Liang, Jie You, Guohai Hu, Xue‐Qi Tian, Sha Liao, Bao‐Quan Fu, Ao Chen, Xue‐Peng Cai, Huanming Yang, Jian Wang, Xin Jin, Xun Xu, Wan‐Zhong Jia, Junhua Li, Hong‐Bin Yan   +35 more
wiley   +1 more source

Clinical Laboratory Assessment of \u3cem\u3eMycoplasma genitalium\u3c/em\u3e Transcription-Mediated Amplification Using Primary Female Urogenital Specimens [PDF]

, 2016
Following analysis of primary cervix, vagina, and first-void female urine specimens for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis via commercial transcription-mediated amplification (TMA), residual material was subjected to ...
Bykowski, Holly, Hryciuk, Jeanne E., Munson, Erik, Munson, Kimber L., Napierala, Maureen, Reiss, Pamela J., Schell, Ronald F.   +6 more
core   +1 more source

Prevalence and genetic diversity of Trichomonas vaginalis clinical isolates in a targeted population in Xinxiang City, Henan Province, China

Parasites & Vectors, 2018
Trichomonas vaginalis (TV) is a protozoan parasite that causes trichomoniasis, a sexually transmitted disease, worldwide. In this study, we investigated the prevalence and genetic characterization of T. vaginalis and contrasted the most prevalent strains
Zhenchao Zhang, Lixia Kang, Weijuan Wang, Xin Zhao, Yuhua Li, Qing Xie, Shuai Wang, Tong He, Han Li, Tingwei Xiao, Yunchao Chen, Suqiong Zuo, L. Kong, Pengju Li, Xiangrui Li   +14 more
semanticscholar   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Volume 6, Issue 5, May 2025.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Trichomonas vaginalis infection in human immunodeficiency virus-seropositive Nigerian women: The public health significance [PDF]

, 2007
Evidence from the biology and epidemiology of Trichomonas vaginalis suggests that this protozoan parasite may play an important role in human immunodeficiency virus (HIV) transmission dynamics, especially where heterosexual behaviour and a high ...
Alo, Moses Nnaemeka, Ogbu, Ogbonnaya, Ugwuoru, Duhu Clifford, Uneke, Chigozie Jesse   +3 more
core   +1 more source

Transcriptomic Identification of Iron-Regulated and Iron-Independent Gene Copies within the Heavily Duplicated Trichomonas vaginalis Genome [PDF]

, 2012
Gene duplication is an important evolutionary mechanism and no eukaryote has more duplicated gene families than the parasitic protist Trichomonas vaginalis.
Basler, Marek, Campo, Neritza B., Horváthová, Lenka, Hrdý, Ivan, Huang, Kuo-Yang, Huang, Po-Jung, Lin, Rose, Shin, Jyh-Wei, Tachezy, Jan, Tang, Petrus, Šafaříková, Lucie   +10 more
core   +1 more source