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Terbinafine Resistance of Trichophyton Clinical Isolates Caused by Specific Point Mutations in the Squalene Epoxidase Gene. [PDF]
Terbinafine is one of the allylamine antifungal agents whose target is squalene epoxidase (SQLE). This agent has been extensively used in the therapy of dermatophyte infections.
Alshahni, M.M.+8 more
core +2 more sources
The epidemic of the multiresistant dermatophyte Trichophyton indotineae has reached China
Due to its high degree of natural resistance to terbinafine in vitro and its tendency to spread globally from the Indian subcontinent, the emerging dermatophyte Trichophyton indotineae has become a major concern in dermatology.
Songgan Jia+8 more
semanticscholar +1 more source
Transmission of dermatophytes, especially Trichophyton mentagrophytes genotype VII, during sexual intercourse has been recently reported. We report 13 such cases in France. All patients were male; 12 were men who have sex with men.
A. Jabet+22 more
semanticscholar +1 more source
A 2-year-old female child admitted to the hospital due to a palpable mass at her scalp referred by her parents. Her past medical history was clear. The clinical examination revealed edema, redness/erythema, blisters, tenderness and itching. No neurological changes were referred, no hair loss occurred and no other areas of the body were affected.
Evangelia Christodoulou, Savas Deftereos
openaire +3 more sources
Trichophyton (T.) indotineae is a newly identified dermatophyte species that has been found in a near-epidemic form on the Indian subcontinent. There is evidence of its spread from the Indian subcontinent to a number of countries worldwide. The fungus is
S. Uhrlass+6 more
semanticscholar +1 more source
Numerous reports of resistance to terbinafine in Trichophyton spp. from all over the world are arousing justified attention and concern. Point mutations in the gene that encodes the squalene epoxidase (SQLE) enzyme are responsible for these therapeutic ...
P. Bortoluzzi+11 more
semanticscholar +1 more source
Trichophyton indotineae and other terbinafine-resistant dermatophytes in North America
Dermatophyte infections (a.k.a. ringworm, tinea) affect an estimated 20%–25% of the world’s population. In North America, most dermatophytoses are caused by Trichophyton rubrum or Trichophyton mentagrophytes species complexes.
S. R. Lockhart+2 more
semanticscholar +1 more source
Extensive Dermatophytosis Caused by Terbinafine-Resistant Trichophyton indotineae, France
Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France.
A. Jabet+13 more
semanticscholar +1 more source
Increasing Terbinafine Resistance in Danish Trichophyton Isolates 2019–2020
Terbinafine resistance in Trichophyton species has emerged and appears to be increasing. A new EUCAST susceptibility testing method and tentative ECOFFs were recently proposed for Trichophyton.
K. Astvad+5 more
semanticscholar +1 more source