Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes [PDF]
In complex with the cosubstrate UDP-N-acetylglucosamine (UDP-GlcNAc),O-linked-GlcNAc transferase (OGT) catalyzes Ser/ThrO-GlcNAcylation of many cellular proteins and proteolysis of the transcriptional coregulator HCF-1.
Bhuiyan, Tanja +6 more
core +3 more sources
Background The transcription factors of the LSF/Grainyhead (GRH) family are characterized by the possession of a distinctive DNA-binding domain that bears no clear relationship to other known DNA-binding domains, with the possible exception of the p53 ...
Kaufman Les +5 more
doaj +1 more source
The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
core +1 more source
Short and random: Modelling the effects of (proto-)neural elongations [PDF]
To understand how neurons and nervous systems first evolved, we need an account of the origins of neural elongations: Why did neural elongations (axons and dendrites) first originate, such that they could become the central component of both neurons and ...
de Wiljes, Oltman O. +2 more
core +3 more sources
Trichoplax adhaerens, nov. gen., nov. spec
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire +1 more source
Growth produces coordination trade-offs in Trichoplax adhaerens, an animal lacking a central nervous system. [PDF]
Davidescu MR +3 more
europepmc +1 more source
Phylogenetic Relationships within the Opisthokonta Based on Phylogenomic Analyses of Conserved Single-Copy Protein Domains [PDF]
Many of the eukaryotic phylogenomic analyses published to date were based on alignments of hundreds to thousands of genes. Frequently, in such analyses, the most realistic evolutionary models currently available are often used to minimize the impact of ...
A. J. Roger +61 more
core +1 more source
The mitochondrial genome structure of Xenoturbella bocki (phylum Xenoturbellida) is ancestral within the deuterostomes [PDF]
Xenoturbellida) is ancestral within the ...
Maximilian J Telford +3 more
core +3 more sources
New mutations in the gene in Czech population with autosomal dominant polycystic kidney disease [PDF]
Background Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. The disease is caused by mutations of the PKD1 (affecting roughly 85% of ADPKD patients) and PKD2 (affecting roughly 14% of ADPKD patients) genes,
Merta Miroslav +7 more
core +2 more sources
Establishment of a transgenic protocol in Trichoplax adhaerens.
Trichoplax adhaerens, one of the simplest multicellular organisms belonging to the phylum Placozoa, occupies a basal position within Metazoa and serves as a critical model for investigating early multicellular evolution. Despite its significance, the absence of functional genetic tools has limited research to comparative genomics, ultrastructural ...
Min-Jun, Jin +6 more
openaire +1 more source

