Results 71 to 80 of about 2,194 (163)

The origin and evolution of G protein-coupled receptor kinases. [PDF]

PLoS ONE, 2012
G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling.
Arcady Mushegian, Vsevolod V Gurevich, Eugenia V Gurevich   +2 more
doaj   +1 more source

CELL TYPES DIVERSITY OF H4 HAPLOTYPE PLACOZOA SP.

, 2019
Placozoa is one of the five basal metazoan lineages critical for our understanding of animal evolution in general, and the origin of neuromuscular organization in particular.
Романова, Д. Ю.
core   +1 more source

DNA Content and Fragmentation of the Egg Nucleus of Trichoplax adhaerens

Zeitschrift für Naturforschung C, 1981
Abstract Under culture conditions the egg nucleus of Trichoplax adhaerens reaches an unusually high and variable DNA content. Before the "fertilization membrane" is formed, the nucleus undergoes fragmentation. It is assumed that culture conditions differ from natural conditions by preventing the switch-over from the S-phase to the G 2 ...
A. Ruthmann, K. G. Grell, G. Benwitz
openaire   +1 more source

Growth produces coordination trade-offs in Trichoplax adhaerens, an animal lacking a central nervous system

, 2023
How collectives remain coordinated as they grow in size is a fundamental challenge affecting systems ranging from biofilms to governments. This challenge is particularly apparent in multicellular organisms, where coordination among a vast number of cells
Romanczuk, Pawel, Davidescu, Mircea R., Couzin, Iain D., Gregor, Thomas   +3 more
core   +1 more source

Global diversity of the Placozoa.

PLoS ONE, 2013
The enigmatic animal phylum Placozoa holds a key position in the metazoan Tree of Life. A simple bauplan makes it appear to be the most basal metazoan known and genetic evidence also points to a position close to the last common metazoan ancestor ...
Michael Eitel, Hans-Jürgen Osigus, Rob DeSalle, Bernd Schierwater   +3 more
doaj   +1 more source

Biophysical Characterization and Evolutionary Analysis of the Presynaptic Voltage-gated calcium (Cav2) Channel in Trichoplax adhaerens [PDF]

, 2018
Trichoplax adhaerens is a primitive metazoan with six cell types that lacks a nervous system and synapses. One cell type, dubbed gland cells, line the periphery of its flat disc- shaped body and resemble neurons by expressing membrane apposed secretory ...
Abdallah, Salsabil
core   +1 more source

ParaHox Genes Revisited: From Gut Patterning to Integrated Axial and Neural Organization in Rotifera

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 4, Page 357-369, June 2026.
In rotifers, ParaHox genes show a dispersed genomic organization, with Xlox absent across gnathiferans. Exclusive neuronal expression of Gsx and Cdx reveals that ancestral ParaHox genes coordinated neural and epithelial development beyond gut patterning, suggesting an integrated role in early bilaterian body plan organization.
Andreas C. Fröbius, David B. Mark Welch, Holger Herlyn   +2 more
wiley   +1 more source

Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. [PDF]

PLoS Genetics, 2013
The evolution of metazoans from their choanoflagellate-like unicellular ancestor coincided with the acquisition of novel biological functions to support a multicellular lifestyle, and eventually, the unique cellular and physiological demands of ...
Melissa Y Frédéric, Victor F Lundin, Matthew D Whiteside, Juan G Cueva, Domena K Tu, S Y Catherine Kang, Hansmeet Singh, David L Baillie, Harald Hutter, Miriam B Goodman, Fiona S L Brinkman, Michel R Leroux   +11 more
doaj   +1 more source

Beyond the Secretory Pathway: New Insights Into Protein Release

Traffic, Volume 26, Issue 10-12, October/December 2025.
While proteins bearing N‐terminal signal or leader sequences are secreted via the ER‐Golgi‐plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequence can be secreted via poorly defined mechanisms termed Unconventional Protein Secretion (UcPS).
Ruey‐Hwa Chen, Antonio J. Costa‐Filho, Jayanta Debnath, Thierry Galli, Liang Ge, Deborah Goberdhan, Wei Guo, Kangmin He, Ralf Jacob, Tiebang Kang, Min Goo Lee, Lian Li, Fabio Lolicato, Jun Lu, Vivek Malhotra, Walter Nickel, Vassiliki Nikoletopoulou, Stacey K. Ogden, Georgia Maria Sagia, Feng Shao, Anbing Shi, Clotilde Thery, Christel Vérollet, Julien Villeneuve, Frederik Verweij, Yanzhuang Wang, Juan Wang, Shenjie Wu, Yihong Ye, Hang Yin, Li Yu, Min Zhang, Ying Zhang, Xin Zhou, Chiara Zurzolo   +34 more
wiley   +1 more source

Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity [PDF]

Nature Communications, 2013
Genome sequencing of arguably the simplest known animal, Trichoplax adhaerens, uncovered a rich array of transcription factor and signalling pathway genes. Although the existence of such genes allows speculation about the presence of complex regulatory events, it does not reveal the level of actual protein expression and functionalization through ...
Jeffrey H. Ringrose, Henk W.P. van den Toorn, Michael Eitel, Harm Post, Pieter Neerincx, Bernd Schierwater, A.F. Maarten Altelaar, Albert J.R.   +7 more
openaire   +2 more sources