Results 41 to 50 of about 2,354 (161)

Defining bone fide effectors of RAS GTPases

BioEssays, Volume 45, Issue 9, September 2023., 2023
RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley   +1 more source

Morphological and physiological aspects of movement and contractility in Trichoplax adhaerens (Placozoa)

, 2011
The Placozoa represent one of the early metazoan branches and are of interest for comparative studieson several evolutionary aspects in the Metazoa. Despite of the relatively simple placozoan morphology,many functional aspects remain partly or completely unknown.
Moeckel, Lars, Paelchen, Katrin, Arnold, Christopher, Hammel, Joerg, Nickel, Michael   +4 more
openaire   +2 more sources

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions

Protein Science, Volume 32, Issue 7, July 2023., 2023
Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish, Niels Theys, Eva Andersson, Per Jemth   +5 more
wiley   +1 more source

Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels

The Journal of Physiology, Volume 601, Issue 9, Page 1625-1653, 1 May 2023., 2023
Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich, Patrick T. N. McCubbin, William R. Schafer, Denise S. Walker   +3 more
wiley   +1 more source

A novel study of Trichoplax adhaerens tissue strain using hot and kiln formed glass processes

, 2023
Tissue monolayers are among the most ubiquitous and simple forms of tissue architecturefound throughout animal physiology. One-cell-thick monolayers have drastic increases in tensile strength compared to individual cellular components, but they remain ...
Delli-Santi, Jack
core   +3 more sources

Apicortin, a Constituent of Apicomplexan Conoid/Apical Complex and Its Tentative Role in Pathogen—Host Interaction

Tropical Medicine and Infectious Disease, 2021
In 2009, apicortin was identified in silico as a characteristic protein of apicomplexans that also occurs in the placozoa, Trichoplax adhaerens. Since then, it has been found that apicortin also occurs in free-living cousins of apicomplexans (chromerids)
Ferenc Orosz
doaj   +1 more source

Insights into the evolution of digestive systems from studies of Trichoplax adhaerens [PDF]

Cell and Tissue Research, 2019
Trichoplax, a member of the phylum Placozoa, is a tiny ciliated marine animal that glides on surfaces feeding on algae and cyanobacteria. It stands out from other animals in that it lacks an internal digestive system and, instead, digests food trapped under its lower surface.
Carolyn L. Smith, Tatiana D. Mayorova
openaire   +2 more sources

A review of the methods used to induce cancer in invertebrates to study its effects on the evolution of species and ecosystem functioning

Methods in Ecology and Evolution, Volume 13, Issue 9, Page 1885-1898, September 2022., 2022
Abstract Cancer is an understudied but important process in wildlife that is predicted to have a significant effect on the evolution of metazoan species due to negative effects on host fitness. However, gaining understanding of the impact of cancer on species and ecosystems is currently relatively slow as the development of both animal models in which ...
Antoine M. Dujon, Justine Boutry, Sophie Tissot, Jordan Meliani, Lena Guimard, Océane Rieu, Beata Ujvari, Frédéric Thomas   +7 more
wiley   +1 more source

Evolution of factors shaping the endoplasmic reticulum

Traffic, Volume 23, Issue 9, Page 462-473, September 2022., 2022
More than 15 proteins have a role in shaping the endoplasmic reticulum (ER) but studies on the evolution of these factors are lacking. Now, a molecular evolutionary analysis indicates that reticulons, REEPs, atlastin, spastin, lunapark, TMEM33, STIM1 and VAPs likely evolved as early as the last eukaryotic common ancestor (LECA).
Aspasia Kontou, Emily K. Herman, Mark C. Field, Joel B. Dacks, V. Lila Koumandou   +4 more
wiley   +1 more source

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal <i>Trichoplax adhaerens</i>. [PDF]

Hypoxia (Auckl), 2018
Background: In humans and other animals, the chronic hypoxic response is mediated by hypoxia inducible transcription factors (HIFs) which regulate the expression of genes that counteract the effects of limiting oxygen.
Lippl K, Boleininger A, McDonough MA, Abboud MI, Tarhonskaya H, Chowdhury R, Loenarz C, Schofield CJ.   +7 more
europepmc   +2 more sources