Results 121 to 130 of about 140,376 (301)

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

open access: yesBritish Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman   +3 more
wiley   +1 more source

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

open access: yesClinical pharmacology and therapy, 2017
J. Hicks   +13 more
semanticscholar   +1 more source

Parasports for cerebral palsy: Thinking and ‘prescribing’ beyond the Paralympics

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
This narrative review synthesizes current evidence on parasport participation for individuals with cerebral palsy, highlighting key benefits, and providing sport‐specific adaptations that enhance accessibility of parasport. Abstract The landscape of care for individuals with cerebral palsy (CP) has evolved far beyond ‘fixing’ impairments toward a life ...
Julia E. Hanes   +5 more
wiley   +1 more source

Exploring Perimenopausal and Menopausal Women's Oral Health Perceptions and Practices in Australia—A Qualitative Study

open access: yesGerodontology, EarlyView.
ABSTRACT Objective To explore the perceptions and practices of women in peri/menopause towards oral healthcare in Australia. Background Hormonal changes associated with peri/menopause create a period where women may be more prone to developing oral health problems, which can significantly impact their quality of life.
Namitha Thomas   +4 more
wiley   +1 more source

5,6-Diphenyl-1,3,4,7-tetra-p-tolyl-1,3,3a,7a-tetrahydropentaleno[1,2-c]furan

open access: yesMolbank
The reaction of (Z)-5-phenyl-1,3-di-p-tolylpent-2-en-4-yn-1-ol (1) with trimethylsilyl chloride in dichloromethane at ambient temperature gave a dimeric ether compound 2 in 30% yield.
Shu-Kai Chen   +2 more
doaj   +1 more source

Reduction of opioid and barbiturate use following initiation of rimegepant for migraine in the United States

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective The primary objective of this study was to evaluate opioid and barbiturate utilization before and after the first prescription of the calcitonin gene–related peptide receptor antagonist rimegepant in individuals with migraine. Background Although not recommended in migraine treatment guidelines, opioids and barbiturates are often ...
Noah Rosen   +6 more
wiley   +1 more source

Acrocyanosis as a side effect of tricyclic antidepressants: a case report

open access: yesThe Turkish Journal of Pediatrics, 2003
Acrocyanosis is probably the most unusual side effect of tricyclic antidepressant drugs. In this paper, we report a 10-year-old boy with primary enuresis nocturna and attention deficit hyperactivity disorder who developed two episodes of ...
Işik Karakaya   +3 more
doaj  

Treatment effectiveness of galcanezumab versus traditional oral migraine preventive medications at 3 months: Results from the TRIUMPH study

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study assesses the 3‐month effectiveness of the calcitonin gene‐related peptide monoclonal antibody galcanezumab versus traditional oral migraine preventive medications. Background Studies comparing the effectiveness of calcitonin gene‐related peptide monoclonal antibodies versus traditional oral migraine preventive medications ...
Richard B. Lipton   +7 more
wiley   +1 more source

Lycocasine A, a Lycopodium Alkaloid from Lycopodiastrum casuarinoides and Its Acid-Sensing Ion Channel 1a Inhibitory Activity

open access: yesMolecules
A novel Lycopodium alkaloid, lycocasine A (1), and seven known Lycopodium alkaloids (2–8), were isolated from Lycopodiastrum casuarinoides. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis.
Shuai Jiang   +3 more
doaj   +1 more source

Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD.
Sanjiv Mahadeva   +28 more
wiley   +1 more source

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