Results 121 to 130 of about 145,419 (376)

Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]

open access: yes, 2019
The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel   +8 more
core   +1 more source

Exploring the Reactivity of Germole Dianions with Aluminum Trichloride: Uncovering Versatile Pathways

open access: yesChemistryEurope, EarlyView.
The reaction of dipotassium germoldiides with donor complexes of AlCl3 reveals an astonishing broad line‐up of products. Key products are Ge(II)alumole complexes, cationic germole complexes of aluminylenes, and a 2H‐germole derivative. Product formation is influenced by the choice of the donor, its size and its stoichiometric ratio.
Lena Albers   +2 more
wiley   +1 more source

Synthetic Study on Bicyclic Pyranonaphthoquinone Natural Products: Construction of the Dioxabicyclo[3.3.1]nonene Motif

open access: yesChemistryEurope, EarlyView.
The method for the stereoselective formation of dioxabicyclo[3.3.1]nonene structure has been developed. The intriguing bicyclic skeleton is embedded in hybrid‐type pyranonaphthoquinone natural products, e.g., glenthamine Treatment of nanaomycin D and naphthol with Na2HPO4 in DMSO and water affords the bicyclic compound in good yield.
Yoshio Ando, Sota Ajima, Ken Ohmori
wiley   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

open access: yesChemistryEurope, EarlyView.
A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato   +6 more
wiley   +1 more source

Tricyclic flavonoids with 1,3-dithiolium substructure

open access: yesBeilstein Journal of Organic Chemistry, 2012
The synthesis of new 3-dithiocarbamic flavonoids has been accomplished by the reaction of the corresponding 2-hydroxyaryl dithiocarbamates with aminals. These flavonoids were obtained as a mixture of diastereoisomers, the anti isomer being the major one.
Lucian G. Bahrin   +2 more
doaj   +1 more source

Indole Synthesis via Allenyl Ester; Enantioselective Total Synthesis of Geissoschizoline

open access: yesChemistryEurope, EarlyView.
An indole synthesis via an allenyl ester intermediate at ambient temperature has been developed. The mild reaction conditions allow the use of a broad range of substrates. Notably, the utility of this approach is demonstrated through the asymmetric total synthesis of geissoschizoline, a Strychnos‐type monoterpenoid indole alkaloid.
Sohsuke Moriue   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy