Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
Respiratory Research, 2023 Introduction The standard therapy for bronchial asthma consists of combinations of acute (short-acting ß2-sympathomimetics) and, depending on the severity of disease, additional long-term treatment (including inhaled glucocorticoids, long-acting ß2 ...
Virag Klein +11 more
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Fullerene (C20) as a potential sensor for thermal and electrochemical detection of amitriptyline: A DFT study [PDF]
Journal of Chemistry Letters, 2020 In this research, amitriptyline adsorption on the surface of fullerene C20 was studied by density functional theory computations. The calculated adsorption energies showed amitriptyline interaction with C20 is experimentally possible. The negative values
Zohreh Doroudi +1 more
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Mechanisms of the Cardiotoxic Action of Amitriptyline
Общая реаниматология, 2011 Objective: to study the mechanisms of toxic action of amitriptyline on the myocardium. Material and methods. Investigations were conducted using the hearts from 30 outbred albino rats, which had been isolated and perfused according to the procedure ...
G. V. Chekmarev, V. T. Dolgikh
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Amitriptyline prescribing in public sector healthcare facilities in the Western Cape, South Africa
PLoS ONE, 2020 BackgroundInappropriate medication use is a major patient safety concern, especially for the elderly population. Amitriptyline is widely used in primary care in South Africa and a cross-sectional study found that amitriptyline was prescribed potentially ...
Mosedi Namane (8735610) +10 more
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Amitriptyline induced cervical dystonia
Journal of the Scientific Society, 2016 Tricyclic antidepressants (TCAs), such as amitriptyline, have many side effects. But extrapyramidal tract symptom is an uncommon side effect of these drugs. Here, we report a case of a 28-year-old male who is suffering from amitriptyline induced cervical
Mahesh Desai +2 more
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Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity
Toxicology and Applied Pharmacology, 2009 9 páginas, 6 figuras. The authors wish to dedicate this manuscript in memoriam to our colleague José A. Mejías Romero.Since amitriptyline is a very frequently prescribed antidepressant drug, it is not surprising that amitriptyline toxicity is relatively ...
Mario D Cordero +2 more
exaly +2 more sources
Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline
Cellular Physiology and Biochemistry, 2016 Background/Aims: Several recent clinical studies revealed an accumulation of ceramide in bronchial epithelial cells of patients with cystic fibrosis (CF).
Gloria Herrmann +8 more
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Effect of amitriptyline on orthodontic tooth movement in rats: an experimental study [PDF]
Journal of Dental Research, Dental Clinics, Dental Prospects, 2020 Background. Orthodontic tooth movement (OTM) occurs in the alveolar bone; therefore, any condition affecting bone quality can alter OTM. This study aimed to evaluate the effect of amitriptyline on OTM in rats. Methods.
Mohammad Sadegh Ahmad Akhoundi +6 more
doaj +1 more source
Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]
Korean Journal of Anesthesiology, 2019 Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim +8 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei +10 more
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