Results 31 to 40 of about 4,707 (142)

Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation

BMC Neurology, 2012
Background Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes.
Cheng Kuang-I, Wang Hung-Chen, Chang Lin-Li, Wang Fu-Yen, Lai Chung-Sheng, Chou Chao-Wen, Tsai Hung-Pei, Kwan Aij-Lie   +7 more
doaj   +1 more source

Evaluation the effect of amitriptyline and/or ashwagandha on body weight in male rats

Al-SalamJournal for Medical Science, 2023
study aims to examine and compare the effects of amitriptyline and ashwagandha on body weight in male rats by measurement weight for 4 weeks after their exposure to these two compound.
Ghada A. Taqa, Ismail R. Idrees
doaj   +1 more source

Voltammetric determination of imipramine hydrochloride and amitriptyline hydrochloride using a polymer-modified carbon paste electrode

, 1996
In this paper the voltammetric behaviors of imipramine HCl and amitriptyline HCl, which are both tricyclic antidepressants, were investigated using a carbon paste electrode, modified by the addition of poly(N-vinylimidazole), in various solutions of ...
Uslu, B, Biryol, I, Kucukyavuz, Z
core   +1 more source

Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Shohreh Taziki, Mohammad Reza Sattari, Siavoush Dastamalchi, Mohammad Ali Eghbal   +3 more
doaj   +1 more source

Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. [PDF]

PLoS ONE, 2011
Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence.
Wayne Chadwick, Nick Mitchell, Jenna Caroll, Yu Zhou, Sung-Soo Park, Liyun Wang, Kevin G Becker, Yongqing Zhang, Elin Lehrmann, William H Wood, Bronwen Martin, Stuart Maudsley   +11 more
doaj   +1 more source

Antidepressants and their effect on sleep

, 2005
Given the relationship between sleep and depression, there is inevitably going to be an effect of antidepressants on sleep. Current evidence suggests that this effect depends on the class of antidepressant used and the dosage.
Mayers, Andrew G., Baldwin, David S., Mayers, A.G., Baldwin, D.S.   +3 more
core   +1 more source

High Concentrations of the Antidepressant Amitriptyline Activate and Desensitize the Capsaicin Receptor TRPV1

Pharmaceuticals
Background: A large number of patients suffer from neuropathic pain, and systemic therapy often remains ineffective while inducing severe side effects. Topical therapy with the TRPV1-agonist capsaicin is an established alternative, and the identification
Sebastian Pantke, Johanna H. Steinberg, Lucas K. H. Weber, Tabea C. Fricke, Inês Carvalheira Arnaut Pombeiro Stein, George Oprita, Christine Herzog, Andreas Leffler   +7 more
doaj   +1 more source

A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia

Biomedicines, 2017
Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have ...
Kim Lawson
doaj   +1 more source

Effects of the Antidepressant Amitriptyline on Juvenile Brown Trout and Their Modulation by Microplastics

Toxics, 2022
Pharmaceuticals such as antidepressants are designed to be bioactive at low concentrations. According to their mode of action, they can also influence non-target organisms due to the phylogenetic conservation of molecular targets.
Hannah Schmieg, Stefanie Krais, Kathrin Kübler, Aki S. Ruhl, Isabelle M. Schmidgall, Christian Zwiener, Heinz-R. Köhler, Rita Triebskorn   +7 more
doaj   +1 more source

Phase 1A safety assessment of intravenous amitriptyline

, 2007
The antidepressant amitriptyline is used as an adjuvant in the treatment of chronic pain. Among its many actions, amitriptyline blocks Na+ channels and nerves in several animal and human models.
Colvin, Hans Peter, Lukanich, Jean, Saria, Alois, Fridrich, Peter, Zernig, Gerald, Zizza, Anthony, Hamp, Thomas, Wasan, Ajay D., Gerner, Peter, Lirk, Philipp   +9 more
core   +1 more source