Results 231 to 240 of about 145,419 (376)

Effects of Tricyclic Antidepressants on Tetrabenazine-Induced Depletion of Brain Monoamines In Rats. 1. Norepinephrine

, 1980
Toshio Yoshizaki, Kanya Tonda
openalex   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Discovery of Pre-Clinical Candidate <b>VU6008055</b>/<b>AF98943</b>: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy. [PDF]

ACS Chem Neurosci
Engers JL, Bollinger SR, Gregro AR, Capstick RA, Spearing PK, Long MF, Tarr JC, Watson KJ, Chang S, Luscombe VB, Rodriguez AL, Cho HP, Qi A, Niswender CM, Bubser M, Gould RW, Robb WH, Byun N, Gore J, Jones CK, Thomsen MS, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +26 more
europepmc   +1 more source

Quinolizidines. XII. Synthetic incorporation of ethyl cincholoiponate into a tricyclic intermediate adaptable to chiral syntheses of the 10-hydroxy-9-methoxybenzo(a)quinolizidine-type Alangium alkaloids.

, 1985
Tozo Fujii, Masashi Ohba, Hitoshi Suzuki
openalex   +2 more sources

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Differences in pharmacological migraine treatment across different levels of clinical headache care - a cross-sectional study. [PDF]

J Headache Pain
Fitzek MP, Overeem LH, Ulrich M, Hong JB, Hoehne CL, Lange KS, Salim Y, Reuter U, Raffaelli B.   +8 more
europepmc   +1 more source

Chemical profiling and characterisation of anthraquinone‐based polyphenols as biocolourants from Cortinarius semisanguineus

Coloration Technology, EarlyView.
Abstract Anthraquinone dyes are known for their significant colour (brightness of shade in the red, blue and green areas) and light fastness properties compared with other synthetic dyes (such as azo‐based dyes). However, challenging multi‐step synthesis of anthraquinones and limited access to fewer substituents result in insufficient reactivity ...
Arvind Negi, Peppi Toukola, Riikka Räisänen   +2 more
wiley   +1 more source

Synthesis of Rhodocorane L Using Gold-Catalyzed Dearomative Spirocyclization. [PDF]

Org Lett
Shimizu EA, Rychnovsky SD.
europepmc   +1 more source

The effect of different exercise types on migraine frequency in individuals with migraine: A pilot study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives This study aimed to evaluate the effects of different types and combinations of exercise on migraine attacks and accompanying comorbidities. Background Combining aerobic and resistance exercises may yield more significant improvements in patients with migraine.
Yunus Emre Meydanal, Seçkin Şenışık, Hadiye Şirin   +2 more
wiley   +1 more source

The relative toxicity of medicines detected after poisoning suicide deaths in Australia, 2013-19: a data linkage case series study. [PDF]

Med J Aust
Lim J, Buckley NA, Chitty K, Schaffer AL, Schumann J, Ali Z, Cairns R.   +6 more
europepmc   +1 more source