Results 231 to 240 of about 140,376 (301)
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Organic Letters, 2020
3,4-Fused tricyclic indole scaffolds are ubiquitous in bioactive natural products and pharmaceuticals. A new protocol for the synthesis of 3,4-fused tricyclic indoles has been developed through cascade carbopalladation and C-H amination with N,N-di-tert ...
Cang Cheng +4 more
semanticscholar +1 more source
3,4-Fused tricyclic indole scaffolds are ubiquitous in bioactive natural products and pharmaceuticals. A new protocol for the synthesis of 3,4-fused tricyclic indoles has been developed through cascade carbopalladation and C-H amination with N,N-di-tert ...
Cang Cheng +4 more
semanticscholar +1 more source
British Journal of Psychiatry, 1976
Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels ≥ 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml.
J, Davidson, B L, Yone
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Twenty-four patients hospitalized for overdose of a tricyclic antidepressant were monitored clinically, and serial plasma-drug measurements were taken for up to 144 hours. Six of 24 patients had maximum antidepressant plasma levels ≥ 1,000 ng/ml, and their plasma levels at 96 hours ranged from 170 to 1,280 ng/ml.
J, Davidson, B L, Yone
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Angewandte Chemie, 2019
Bicyclic and tricyclic peptides have emerged as promising candidates for the development of protein binders and new therapeutics. However, convenient and efficient strategies that can generate topologically controlled bicyclic and tricyclic peptide ...
Yizhen Yin +5 more
semanticscholar +1 more source
Bicyclic and tricyclic peptides have emerged as promising candidates for the development of protein binders and new therapeutics. However, convenient and efficient strategies that can generate topologically controlled bicyclic and tricyclic peptide ...
Yizhen Yin +5 more
semanticscholar +1 more source
Tricyclic Antidepressant Agranulocytosis
The Canadian Journal of Psychiatry, 1986Severe neutropenia is an unusual complication of antidepressant therapy. We report a case of agranulocytosis due to clomipramine, and discuss principles of management.
D S, Gravenor, J R, Leclerc, G, Blake
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Tricyclic Antidepressant Overdose
Pediatric Clinics of North America, 1986Overdose of a tricyclic antidepressant is a serious and all-too-frequent occurrence. The diagnosis must be considered in known or suspected overdoses, and signs such as a dry axilla, tachycardia, and wide QRS must be specifically sought. Management depends upon support of vital functions and a thorough understanding of the pharmacology of the drug ...
N J, Braden, J E, Jackson, P D, Walson
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Tricyclic antidepressant poisoning
Medical Journal of Australia, 1991To review poisoning with tricyclic antidepressants.English language literature search using Australian Medlars Service (1977-1989), manual search of journals and review of bibliographies in identified articles.Approximately 250 articles, abstracts and book chapters were selected for analysis.The literature was reviewed and 93 articles were selected as ...
L J, Dziukas, J, Vohra
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Monitoring Tricyclic Antidepressants
Therapeutic Drug Monitoring, 1980As a result of their slow onset of action, the difficulty of assessing dose-effect, and the marked interindividual variability of steady-state plasma concentration, tricyclic antidepressants present a special challenge, as well as opportunity, for therapeutic drug monitoring. As shown particularly by the twin studies of Alexanderson, the most important
F, Sjöqvist, L, Bertilsson, M, Asberg
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Chemistry – A European Journal, 2015
AbstractThe reaction of the functionalized cyclo‐tetraphosphane [ClP(μ‐PMes*)]2 (Mes*=2,4,6‐tri‐tert‐butylphenyl) with different Lewis bases led to the formation of an unprecedented tricyclic hexaphosphane, Mes*P6Mes*. The formation of this compound was investigated by spectroscopic and theoretical methods, revealing an unusual ring expansion reaction.
Jonas, Bresien +2 more
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AbstractThe reaction of the functionalized cyclo‐tetraphosphane [ClP(μ‐PMes*)]2 (Mes*=2,4,6‐tri‐tert‐butylphenyl) with different Lewis bases led to the formation of an unprecedented tricyclic hexaphosphane, Mes*P6Mes*. The formation of this compound was investigated by spectroscopic and theoretical methods, revealing an unusual ring expansion reaction.
Jonas, Bresien +2 more
openaire +2 more sources
Tricyclic Antidepressant Overdose
The Journal of Emergency Medicine, 2008Q a a r. Pooja Agrawal: Today’s case is that of a 64-year-old oman who was brought in to the Emergency Department y Emergency Medical Services after an apparent suiide attempt. The patient was upset that her husband was till communicating with his ex-wife, who lived in their uilding.
Pooja, Agrawal +2 more
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