JAMA Netw Open, 2023 Key Points Question Does pharmacogenetics-informed (CYP2D6 and CYP2C19 genotypes) dosing of tricyclic antidepressants result in faster attainment of therapeutic plasma concentrations, higher effectiveness, and fewer and less severe adverse effects ...
Vos CF +11 more
europepmc +2 more sources
Management of Chronic Tension-Type Headache With Tricyclic Antidepressant Medication, Stress Management Therapy, and Their Combination [PDF]
Journal of the American Medical Association (JAMA), 2001 CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and pharmacological therapies each appear modestly effective, but data are lacking on their separate and ...
Kenneth A. Holroyd +5 more
openalex +2 more sources
Case report: successful lipid resuscitation in multi-drug overdose with predominant tricyclic antidepressant toxidrome [PDF]
International Journal of Emergency Medicine, 2012 We report a case of profound neurologic and cardiovascular manifestations of tricyclic antidepressant intoxication following self-poisoning with multiple pharmaceuticals including amitriptyline in excess of 43 mg/kg, in a 51-year-old male. Institution of
Grant Cave, Martyn Harvey
core +2 more sources
Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]
Journal of Mind and Medical Sciences, 2019 The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel +8 more
core +3 more sources
Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016–2020 [PDF]
British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1727-1738, June 2025.Abstract Aims Tricyclic antidepressants (TCAs) are commonly prescribed despite no longer being a NICE‐recommended first‐line treatment for depression and their recognized toxicity in overdose. This study examined prescribing, mortality, hospital admissions and clinical TCA data to quantify the use and impact of TCAs in England and Wales.
Laurence Gray +10 more
wiley +2 more sources
The Association between Antidepressant Medications and Coronary Heart Disease in Brazil: A Cross-Sectional Analysis on the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil) [PDF]
Frontiers in Public Health, 2015 Background: Recent studies have highlighted associations between use of antidepressant medications and coronary heart disease (CHD). Tricyclic antidepressants are not recommended in patients with CHD as they may increase morbidity and mortality. However,
Aquino +32 more
core +4 more sources
Severe Amitriptillin Intoxication Treated with Intravenous Lipid Emulsion
Journal of Pediatric Emergency and Intensive Care Medicine, 2021 Intoxication with tricyclic antidepressant drugs causes serious toxic findings even at low doses. Despite common use of the antidepressant drugs, there are no randomized controlled trials about treatments in tricyclic antidepressant drug intoxication ...
Ayyüce Ünlü +4 more
doaj +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Ibrain, EarlyView., 2023 This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju +7 more
wiley +1 more source
Impact of Opioid and Cannabis Use on Low‐Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real‐World Study in the United Kingdom [PDF]
Neurogastroenterology &Motility, Volume 37, Issue 6, June 2025.This article presents the outcomes of a three‐tiered outpatient treatment algorithm for the prophylactic management of cyclical vomiting syndrome (CVS). Three key messages: (1) 61% of patients responded to the treatment algorithm, (2) opioid cessation was associated with clinical response to the treatment algorithm (p = 0.03), and (3) a low‐dose ...
Mohsin F. Butt +4 more
wiley +2 more sources