Results 271 to 280 of about 157,293 (343)

Tricyclic Antidepressant Cardiotoxicity

JAMA: The Journal of the American Medical Association, 1976
THE FOOD and Drug Administration (FDA) recently convened a conference of experts to review the question of cardiotoxicity of tricyclic antidepressant (TCA) drugs. 1 The main impetus for this meeting was concern over reports of changes detected in the electrocardiograms (ECGs) of children receiving imipramine hydrochloride at a dosage of 5 mg/kg 2,3 and
Donald S. Robinson, Eileen Barker
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Tricyclic antidepressant overdose

Journal of the American College of Emergency Physicians, 1979
First introduced in the early 1960s, tricyclic antidepressants (TCAs) have been seen increasingly in overdoses, accounting for 10% to 20% of all cases. 1-5 This is not surprising, for amitriptyline was the 29th most frequently prescribed drug in the United States in 1974.
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Tricyclic Antidepressant Overdose

The Journal of Emergency Medicine, 2008
Q a a r. Pooja Agrawal: Today’s case is that of a 64-year-old oman who was brought in to the Emergency Department y Emergency Medical Services after an apparent suiide attempt. The patient was upset that her husband was till communicating with his ex-wife, who lived in their uilding.
David F.M. Brown, Eric S. Nadel, Eric S. Nadel, Pooja Agrawal   +3 more
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Tricyclic antidepressant plasma levels and adverse effects after overdose

Clinical pharmacology and therapy, 1977
Forty patients ingesting tricyclic antidepressant (TAD) overdoses were studied as a pharmacologic model to determine whether total tricyclic antidepressant plasma levels correlated with major adverse effects and electrocardiographic findings. Maximum TAD
James M. Petit, D. Spiker, J. Ruwitch, V. Ziegler, A. Weiss, J. Biggs   +5 more
semanticscholar   +1 more source

Tricyclic antidepressant poisoning. Reversal of coma, choreoathetosis, and myoclonus by physostigmine.

Journal of the American Medical Association (JAMA), 1974
Two patients with coma, choreoathetoid movements, and myoclonus were found to be poisoned with tricyclic antidepressants. Physostigmine salicylate, a centrally active anticholinergic agent, promptly reversed the neurologic abnormalities. It appears to be
J. Burks, J. E. Walker, B. Rumack, J. Ott   +3 more
semanticscholar   +1 more source

Relationship between age and tricyclic antidepressant plasma levels.

American Journal of Psychiatry, 1977
Older depressed patients treated with imipramine or amitriptyline developed higher steady-state plasma levels of imipramine, desipramine, and amitriptyline.
A. Nies, D. Robinson, M. Friedman, R. Green, T. Cooper, Ravaris Cl, J. Ives   +6 more
semanticscholar   +1 more source

Monitoring Tricyclic Antidepressants

Therapeutic Drug Monitoring, 1980
As a result of their slow onset of action, the difficulty of assessing dose-effect, and the marked interindividual variability of steady-state plasma concentration, tricyclic antidepressants present a special challenge, as well as opportunity, for therapeutic drug monitoring. As shown particularly by the twin studies of Alexanderson, the most important
Folke Sjöqvist, Leif Bertilsson, Marie Åsberg   +2 more
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Platelet alpha 2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment.

Archives of General Psychiatry, 1981
The specific binding of tritiated (3H)-clonidine, an alpha 2-adrenergic receptor agonist, to platelet membranes was measured in normal subjects and in patients with major depressive disorder.
J. A. García-Sevilla, Athanasios P. Zis, P. J. Hollingsworth, J. Greden, Charles B. Smith   +4 more
semanticscholar   +1 more source

Tricyclic Antidepressant Overdose: Incidence of Symptoms

, 1977
Forty consecutively hospitalized patients who had overdosed primarily with a tricyclic antidepressant (TCA) were observed until discharge. The severity of the overdose was documented by serial measurements of plasma TCA levels.
J. Biggs, D. Spiker, J. Petit, V. Ziegler   +3 more
semanticscholar   +1 more source

Brugada Syndrome Mimicked by Tricyclic Antidepressant Overdose

Cardiovascular Electrophysiology, 2001
A 33-year-old man was successfully resuscitated from an out-of-hospital episode of ventricular Ž brillation. Upon admission, an ECG showed sinus rhythm with a right bundle branch block, prolonged QTc interval of 526 msec, and downsloping ST elevation ...
H. Tada, C. Sticherling, H. Oral, F. Morady   +3 more
semanticscholar   +1 more source