Results 91 to 100 of about 300 (133)
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Superacid‐Catalyzed Trifluoromethylthiolation of Aromatic Amines
Angewandte Chemie, 2016AbstractUpon activation under superacid conditions, functionalized tailor‐made N‐SCF3 sulfenamides served as reagents for the trifluoromethylthiolation of aromatic amines. This method has a broad substrate scope and can be used for the late‐stage functionalization of complex molecules such as alkaloids or steroids.
Bonazaba milandou, Longin Justin Clair +9 more
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Trifluoromethylthiolation of 1,3-Dithiane
Phosphorus, Sulfur, and Silicon and the Related Elements, 2006With a view to synthesize 2-(trifluoromethylthio)-1,3-dithiane (1), 1,3-dithiane (2) was reacted in dry pentane at −78°C under dry N2 with trifluoromethylsulfenyl chloride (3) and was found to furnish the desired compound in poor yields along with ten other compounds.
S. Munavalli +3 more
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Copper-Mediated Trifluoromethylthiolation of α-Diazoesters
Organic Letters, 2014A novel Cu-mediated trifluoromethylthiolation of diazo compounds has been developed that provides a convenient synthetic route for the efficient α-trifluoromethylthiolation of simple esters under mild reaction conditions. The reaction is typically carried out at room temperature, and water could be used to promote the reaction.
Mingyou, Hu +5 more
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Silver-Mediated Trifluoromethylthiolation–Iodination of Arynes
Organic Letters, 2016A one-pot trifluoromethylthiolation-iodination of arynes with trifluoromethylthiosilver (AgSCF3) and 1-iodophenylacetylene is described. This protocol allows rapid construction of o-trifluoromethylthiolated arene building blocks in moderate yields.
Yuwen, Zeng, Jinbo, Hu
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State‐of‐the‐Art in Electrophilic Trifluoromethylthiolation Reagents
Chinese Journal of Chemistry, 2016AbstractThis work proposed a label‐free, cost‐effective and fairly sensitive electrogenerated chemiluminescence (ECL) strategy for the specific detection of lysozyme based on the hemin/G‐quadruplex hybrid. Gold nanoparticles were spread onto the chitosan thin‐film as substrate to adsorb thiolated captures: a hairpin‐structured DNA, integrating dual ...
Chachignon, Hélène, Cahard, Dominique
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Organic Chemistry Frontiers, 2018
A visible-light photocatalytic trifluoromethylthiolation of aryl amine through in situ generation of aryldiazonium salts with S -trifluoromethyl 4-methoxylbenzenesulfonothioate was developed.
Xia Zhao +7 more
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A visible-light photocatalytic trifluoromethylthiolation of aryl amine through in situ generation of aryldiazonium salts with S -trifluoromethyl 4-methoxylbenzenesulfonothioate was developed.
Xia Zhao +7 more
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Shelf-Stable Electrophilic Reagents for Trifluoromethylthiolation
Accounts of Chemical Research, 2015Fluorine, which is the most electronegative element and has a small atomic radius, plays a key role in pharmaceutical, agrochemical, and materials sciences. One of the fluoroalkyl groups, the trifluoromethylthio group (CF3S-), has been well-recognized as an important structural motif in the design of lead compounds for new drug discovery because of its
Xinxin, Shao +3 more
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Mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide
Organic & Biomolecular Chemistry, 2015A straightforward and convenient approach for trifluoromethylthiolation of various acyclic and cyclic ketones with PhNHSCF 3 is described. The reaction proceeds smoothly in the presence of acetyl chloride at room temperature and affords α-trifluoromethylthiolated ketones in fair to good ...
Wei, Wu +3 more
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Pd-Catalyzed Diastereoselective Trifluoromethylthiolation of Functionalized Acrylamides
Organic Letters, 2017The Pd-catalyzed diastereoselective trifluoromethylthiolation of acrylamides was developed to allow the formation of the Z-isomer as a single product. Using a C-H bond functionalization strategy, the method was applied to a broad range of α-aryl, α-alkyl, and α,β-disubstituted acrylamides bearing the amide derived from the 8-aminoquinoline as a ...
Zhao, Qun +4 more
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