Results 71 to 80 of about 2,600,662 (296)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Three dimensional fast tracker for central drift chamber based level 1 trigger system in the Belle II experiment

, 2017
The Belle II detector at the SuperKEKB accelerator has a level 1 trigger implemented in field-programmable gate arrays. Due to the high luminosity of the beam, a trigger that effectively rejects beam induced background is required.
Kim, J. B., Ko, B. R., Won, E.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The SiSMUV Project: Development and Characterization of SiPM-Based UV-Light Detectors for Space Telescope Applications

Particles
The study of Ultra-High-Energy Cosmic Rays is made possible by space telescopes that allow for the recording of signals generated by Extensive Air Showers (EAS) on the night side of the Earth’s atmosphere.
Valentina Scotti, Giuseppe Osteria, Marco Mese, Antonio Anastasio, Alfonso Boiano, Isaac Buckland, Vincenzo Masone, Riccardo Munini, Beatrice Panico, Haroon Akhtar Qureshi   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Development and validation of saving mothers score: A comprehensive scoring system for early identification of sick mothers

Journal of Obstetric Anaesthesia and Critical Care, 2018
Context: Early identification of high-risk parturient and maternal physiological deterioration may reduce maternal morbidity and mortality. Aims: This study aimed to develop a comprehensive scoring system 'Saving Mothers Score' (SMS) to identify the sick
Kousalya Chakravarthy, Sunil T Pandya, Praveen K Nirmalan   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Triggers for multiple sclerosis relapse in Saudi Arabia: An exploratory cross-sectional study

Journal of Family and Community Medicine
BACKGROUND: Multiple sclerosis (MS) is an autoimmune demyelinating inflammatory disease that affects the central nervous system. Relapse of MS involves the development of new MS-related neurological symptoms or the worsening of existing symptoms for at ...
Foziah J. Alshamrani, Azra Zafar, Mona H. AlSheikh, Abdullah S. Alamri, Alaa K. Alshammari, Modhi S. Alajmi, Mohammad A. Zeeshan, Ibrahim A. Alghnimi, Ghadeer M. Fardan, Mohammed F. Almuaigel   +9 more
doaj   +1 more source

Stress in the Volunteer Caregiver: Human-Centric Technology Can Support Both Caregivers and People with Dementia

Medicina, 2020
Background and Objectives: Currently, one in eight people over the age of 65 have dementia, and approximately 75% of caregiving is provided by volunteer family members with little or no training.
Barbara Huelat, Sharon T. Pochron
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source