Animal Models and Experimental Medicine, EarlyView.We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu +10 more
wiley +1 more source
Apolipoprotein C-III: Risk-factor, Regulator of Triglyceride-rich Lipoprotein Metabolism and Therapeutic Target. [PDF]
Curr Atheroscler RepBjörnson E +4 more
europepmc +1 more source
Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis
Animal Models and Experimental Medicine, EarlyView.This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding +10 more
wiley +1 more source
Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis
International Journal of General MedicineLingling Zhu,1– 3 Linglin Tian,3 Suxia Li,1 Lijuan Huo3 1First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Linfen Vocational and Technical College, Linfen, Shanxi, People’s Republic of China ...
Zhu L, Tian L, Li S, Huo L
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Exploring the association between 5 different alternative indicators of insulin resistance and the risk of multiple cardiovascular and metabolic diseases: A cross-sectional NHANES study from 2005 to 2018. [PDF]
Medicine (Baltimore)Song X, He Y, Cai Z, Peng L.
europepmc +1 more source
Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats
Animal Models and Experimental Medicine, EarlyView.Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček +3 more
wiley +1 more source
Hypertriglyceridaemia-Associated Acute Pancreatitis: Risk Stratification, Drivers, and Prevention of Recurrence. [PDF]
DiseasesFogacci F, Cicero AFG.
europepmc +1 more source
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
Journal of Clinical Investigation, 2004 Mitsuhiro Watanabe +7 more
semanticscholar +1 more source
Annals of Neurology, EarlyView.Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios +5 more
wiley +1 more source
Falsely decreased triglyceride concentration in a patient with acute pancreatitis due to insufficient configuration of alarm rules. [PDF]
Biochem Med (Zagreb)Liu Y, Liu Q, Feng B, Gan W.
europepmc +1 more source