Results 31 to 40 of about 517,171 (297)

Lipid implants for controlled release of proteins [PDF]

, 2007
In recent years, we have seen significant progress towards understanding the role of proteins in both physiological and pathological processes. Especially neurotrophic factors have increasingly come into focus for the treatment of neurodegenerative ...
Könnings, Stephanie
core   +1 more source

Serum Adropin as a Potential Biomarker for Predicting the Development of Type 2 Diabetes Mellitus in Individuals With Metabolic Dysfunction-Associated Fatty Liver Disease

Frontiers in Physiology, 2021
Background: Adropin, a peptide translated from the Energy Homeostasis Associated gene (ENHO), was mainly expressed in the liver and was a regulator in metabolic and energy homeostasis.
Na Li, Guomin Xie, Guomin Xie, Biao Zhou, Aijuan Qu, Aijuan Qu, Hua Meng, Jia Liu, Guang Wang   +8 more
doaj   +1 more source

Clinical and molecular characterization of familial chylomicronemia in Saudi patients: a retrospective study

Frontiers in Endocrinology
IntroductionFamilial chylomicronemia syndrome (FCS) is a severe type of hypertriglyceridemia (HTG). Despite its rarity, we have encountered more than 100 patients with FCS at our center. Therefore, we aimed to provide a useful resource for clinicians who
Abdullah Al-Ashwal, Manal AlHelal, Afaf AlSagheir, Areej Alfattani, Khushnooda Ramzan, Faiqa Imtiaz, Raghad Alhuthil   +6 more
doaj   +1 more source

Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2018
Pulmonary tuberculosis (TB) exhibits granulomatous inflammation, a site of controlling bacterial dissemination at the cost of host tissue damage. Intrigued by the granuloma type-dependent expression of inflammatory markers in TB, we sought to investigate
Neetika Jaisinghani, Neetika Jaisinghani, Stanzin Dawa, Stanzin Dawa, Kaurab Singh, Kaurab Singh, Ananya Nandy, Ananya Nandy, Dilip Menon, Dilip Menon, Purva Deepak Bhandari, Purva Deepak Bhandari, Garima Khare, Anil Tyagi, Anil Tyagi, Sheetal Gandotra, Sheetal Gandotra   +16 more
doaj   +1 more source

Differential Roles of Two Leptin Gene Paralogues on Food Intake and Hepatic Metabolism Regulation in Mandarin Fish

Frontiers in Endocrinology, 2020
Leptin affects food intake regulation and energy homeostasis in mammals, as opposed to mammals who have a single leptin gene, fish have duplicated leptin gene paralogues.
Xiao-Chen Yuan, Xiao-Chen Yuan, Xu-Fang Liang, Xu-Fang Liang, Wen-Jing Cai, Wen-Jing Cai, Ai-Xuan Li, Ai-Xuan Li, Dong Huang, Dong Huang, Shan He, Shan He   +11 more
doaj   +1 more source

INSIG1 influences obesity-related hypertriglyceridemia in humans [PDF]

, 2010
In our analysis of a quantitative trait locus (QTL) for plasma triglyceride (TG) levels [logarithm of odds (LOD) = 3.7] on human chromosome 7q36, we examined 29 single nucleotide polymorphisms (SNPs) across INSIG1, a biological candidate gene in the ...
Carless, M., Blangero, J., Kissebah, A., Curran, J., Cole, R., Dyer, T. D., Curran, Joanne E., Carless, Melanie A., Olivier, M. (Michael), Dyer, T., Abraham, L., Moses, Eric, Martin, L. J. (Lisa J.), Gawrieh, S., Olivier, M., Zhang, Y., Baye, T., Smith, Edward M., Baye, T. M., Kissebah, Ahmed, Abraham, L. J., Moses, E. K. (Eric Keith), Martin, L., Smith, E.   +23 more
core   +1 more source

Triglyceride-inflammation score established on account of random survival forest for predicting survival in patients with nasopharyngeal carcinoma: a retrospective study

Frontiers in Immunology
ObjectiveThis study aimed to establish an effective prognostic model based on triglyceride and inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), to predict ...
Jun Li, Jun Li, Yinxin Ye, Yinxin Ye, Yonglin Cai, Huojin Ji, Huojin Ji, Weiling Qin, Weiling Qin, Yonglin Luo, Yonglin Luo, Xiaoying Zhou, Zhe Zhang, Xue Xiao, Bin Zhang   +14 more
doaj   +1 more source

Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Diabetic dyslipidaemia is characterised by hypertriglyceridaemia, low High Density Lipoprotein (HDL), postprandial lipaemia, small and dense LDL particles is considered to be a major predisposing factor for various macrovascular ...
Shaylika Chauhan, Hanish Kodali, Jawad Noor, Karuna Ramteke, Vidisha Gawai   +4 more
doaj   +1 more source

Structural investigations of the regio- and enantioselectivity of lipases [PDF]

, 1998
Although lipases are widely applied for the stereospecific resolution of racemic mixtures of esters, the atomic details of the factors that are responsible for their stereospecificity are largely obscure. We determined the X-ray structures of Pseudomonas
Dietmar A Lang, Dietmar A. Lang, Bauke W Dijkstra, Lang, Dietmar A., Dijkstra, Bauke W., Dijkstra, Bauke W.,, Bauke W. Dijkstra, Lang, Dietmar A.,   +7 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source